135144-30-8 Usage
Type of compound
Synthetic steroid hormone and progestin medication
Uses
a. Treatment of menstrual disorders
b. Treatment of endometriosis
c. Component of hormonal contraception
Chemical relation
Related to progesterone
Activity
Potent progestogenic activity
Function
Regulates menstrual cycle and prevents unwanted pregnancies
Administration
Typically taken orally in the form of a pill
Absorption
Well absorbed by the body
Additional studies
a. Hormone replacement therapy
b. Transgender hormone therapy
Investigated for
Potential use in the treatment of breast cancer
Versatility
Important chemical compound with a variety of medical applications
Check Digit Verification of cas no
The CAS Registry Mumber 135144-30-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,1,4 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 135144-30:
(8*1)+(7*3)+(6*5)+(5*1)+(4*4)+(3*4)+(2*3)+(1*0)=98
98 % 10 = 8
So 135144-30-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H28O2/c1-3-18(22)21-12-5-4-6-14(21)7-8-15-16-9-10-19(23)20(16,2)13-11-17(15)21/h1,6,15-18,22H,4-5,7-13H2,2H3/t15-,16-,17-,18-,20-,21+/m0/s1
135144-30-8Relevant articles and documents
Synthesis and Biochemical Studies of 16- or 19-Substituted Androst-4-enes as Aromatase Inhibitors
Numazawa, Mitsuteru,Mutsumi, Ayako,Hoshi, Kumiko,Oshibe, Mariko,Ishikawa, Etsushi,Kigawa, Hiroki
, p. 2496 - 2504 (2007/10/02)
Androst-4-en-17-one derivatives and androst-4-en-17β-ol derivatives 3, 5, 10, 12, and 19 were synthesized and tested for their ability to inhibit aromatase in human placental microsomes.All the 17-oxo steroids, except compound 25 and 17,19-diol 3 of this series, were effective competitive inhibitors with apparent Ki's ranging from 170 to 455 nM. 19,19-Difluoro steroid 18 and 19-acetylenic alcohol 25, a weak competitive inhibitor (Ki = 7.75 μM), caused a time-dependent, pseudo-first-order inactivation of aromatase activity with kinact's of 0.0213 and 0.1053 min-1 for compounds 18 and 25, respectively.NADPH and oxygen were required for the time-dependent inactivation, and the substrate, androst-4-ene-3,17-dione, prevented it, but a nucleophile, L-cysteine, did not in each case.The results strongly suggest that aromatase would attack the 19-carbon of steroids 18 and 25.
