13582-93-9

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• Basic information

  1. Product Name: 3,4-dihydro-2h-4-benzoxazine-2-carboxamide
  2. Synonyms: 3,4-dihydro-2h-4-benzoxazine-2-carboxamide;3,4-DIHYDRO-2H-1,4-BENZOXAZINE-2-CARBOXAMIDE;3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide
  3. CAS NO:13582-93-9
  4. Molecular Formula: C₉H₁₀N₂O₂
  5. Molecular Weight: 178.19
  6. EINECS: N/A
  7. Product Categories: Benzomorpholines & Benzothiomorpholines;Benzomorpholines & Benzothiomorpholines
  8. Mol File: 13582-93-9.mol
  9. Article Data: 3

• Chemical Properties

  1. Melting Point: 145-148 °C
  2. Boiling Point: 444.3°Cat760mmHg
  3. Flash Point: 222.5°C
  4. Appearance: /
  5. Density: 1.256g/cm³
  6. Vapor Pressure: 4.32E-08mmHg at 25°C
  7. Refractive Index: 1.575
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. PKA: 14.73±0.20(Predicted)
  11. CAS DataBase Reference: 3,4-dihydro-2h-4-benzoxazine-2-carboxamide(CAS DataBase Reference)
  12. NIST Chemistry Reference: 3,4-dihydro-2h-4-benzoxazine-2-carboxamide(13582-93-9)
  13. EPA Substance Registry System: 3,4-dihydro-2h-4-benzoxazine-2-carboxamide(13582-93-9)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 13582-93-9(Hazardous Substances Data)

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• 3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-2-CARBOXAMIDE

  Cas No: 13582-93-9

• USD $ 3.0-3.0 / Kilogram

• 1 Kilogram

• 1-100 Metric Ton/Month

• Dayang Chem (Hangzhou) Co.,Ltd.
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• 2H-1,4-Benzoxazine-2-carboxamide,3,4-dihydro-

  Cas No: 13582-93-9

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• Hangzhou J&H Chemical Co., Ltd.
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• 3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-2-CARBOXAMIDE HCL

  Cas No: 13582-93-9

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• Hangzhou Fandachem Co.,Ltd
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• 3,4-dihydro-2h-4-benzoxazine-2-carboxamide

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• ZHEJIANG JIUZHOU CHEM CO.,LTD
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• 3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

  Cas No: 13582-93-9

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• Shanghai Run-Biotech Co., Ltd.
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• 3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxaMide

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• Shanghai chamflyer chemicals Co., Ltd
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• 3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide

  Cas No: 13582-93-9

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13582-93-9 Usage

General Description

3,4-dihydro-2H-4-benzoxazine-2-carboxamide is a chemical compound commonly used as a building block for various biologically active molecules. It belongs to the class of benzoxazine derivatives, which have been studied for their potential pharmaceutical applications. 3,4-dihydro-2h-4-benzoxazine-2-carboxamide possesses a cyclic structure containing a benzene ring fused to an oxazine ring, as well as an amide functional group. Its chemical properties make it suitable for use in drug discovery and development, as well as in the preparation of various organic compounds with potential therapeutic effects. Research on the biological activities and pharmacological potential of 3,4-dihydro-2H-4-benzoxazine-2-carboxamide continues to expand, reflecting its significance in the field of medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 13582-93-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,5,8 and 2 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 13582-93:
(7*1)+(6*3)+(5*5)+(4*8)+(3*2)+(2*9)+(1*3)=109
109 % 10 = 9
So 13582-93-9 is a valid CAS Registry Number.

InChI:InChI=1/C9H10N2O2/c10-9(12)8-5-11-6-3-1-2-4-7(6)13-8/h1-4,8,11H,5H2,(H2,10,12)/t8-/m1/s1

13582-93-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name	3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide

1.2 Other means of identification

Product number	-
Other names	2H-1,4-BENZOXAZINE-2-CARBOXAMIDE,3,4-DIHYDRO

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13582-93-9 SDS

13582-93-9Upstream product

• 95-55-6 2-amino-phenol 
• 35017-54-0 ethyl 4-tosyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate 
• 22244-22-0 ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-2-carboxylate 
• 96988-61-3 4-tosyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide 
• 82756-71-6 3,4-Dihydro-2H-1,4-benzoxazin-2-carbnsaeuremethylester 

13582-93-9Downstream Products

• 92659-38-6 Benzomorpholin-thiocarbonsaeure-(2)-amid 
• 212578-42-2 4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide 

13582-93-9Relevant articles and documents

Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1

Spinck, Martin,Bischoff, Matthias,Lampe, Philipp,Meyer-Almes, Franz-Josef,Sievers, Sonja,Neumann, Heinz

supporting information, p. 5838 - 5849 (2021/06/01)

Sirtuins are signaling hubs orchestrating the cellular response to various stressors with roles in all major civilization diseases. Sirtuins remove acyl groups from lysine residues of proteins, thereby controlling their activity, turnover, and localization. The seven human sirtuins, SirT1-7, are closely related in structure, hindering the development of specific inhibitors. Screening 170,000 compounds, we identify and optimize SirT1-specific benzoxazine inhibitors, Sosbo, which rival the efficiency and surpass the selectivity of selisistat (EX527). The compounds inhibit the deacetylation of p53 in cultured cells, demonstrating their ability to permeate biological membranes. Kinetic analysis of inhibition and docking studies reveal that the inhibitors bind to a complex of SirT1 and nicotinamide adenine dinucleotide, similar to selisistat. These new SirT1 inhibitors are valuable alternatives to selisistat in biochemical and cell biological studies. Their greater selectivity may allow the development of better targeted drugs to combat SirT1 activity in diseases such as cancer, Huntington's chorea, or anorexia.

Synthesis of 2-(2-imidazolinyl)substituted 2,3-dihydro-4h-1,4-benzothiazine and 3,4-dihydro-2h-1,4-benzoxazines

Butler,Chapleo,Myers,Welbourn

, p. 177 - 181 (2007/10/02)

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