135999-99-4Relevant articles and documents
SYNTHESIS OF TWO NEW THIAZOLE-CONTAINING OLIGOPEPTIDES AS POTENTIAL DNA MINOR GROOVE BINDING ANALOGS OF NETROPSIN
Plouvier, Bertrand,Bailly, Christian,Houssin, Raymond,Henichart, Jean-Pierre
, p. 693 - 701 (2007/10/02)
On the basis of previous studies on synthetic models related to the antibiotic agents Netropsin and Distamycin-A, the design and synthesis of two potential DNA minor groove ligands are described.Methia-Nt and Isothia-Nt were prepared by liquid-phase peptidic synthesis from the key compounds ethyl 2-amino-5-methylthiazole-4-carboxaldehyde (1) and ethyl 2-aminothiazole-5-carboxylate (8) respectively.