136916-26-2Relevant articles and documents
Asymmetric synthesis of Boc-β2-homophenylglycine
Ponsinet, Rachel,Chassaing, Gerard,Lavielle, Solange
, p. 865 - 871 (1998)
Enantiomerically pure Boc-β2-homophenylglycine has been prepared in five steps starting from Oppolzer's sultam. The key step of this route is the acylation of metalated phenylacetonitrile with sultam carbonyl chloride. Subsequent reactions (reduction, N-Boc protection, oxidation of the Boc- amino alcohol) led to Boc-(S)-β2-HPhg starting from (+)-sultam.
A Heterodinuclear asymmetric catalyst for conjugate additions of α-hydroxyketones to β-substituted nitroalkenes
Trost, Barry M.,Hisaindee, Soleiman
, p. 6003 - 6005 (2007/10/03)
(Chemical Equation Presented) The bis-ProPhenol ligand was designed to facilitate formation of hetereodinuclear complexes based upon the large difference in pKa of the one phenolic OH group to the tertiary OH groups. In exploring the first exam
Palladium-catalysed asymmetric allylic substitution: Synthesis of α- and β-amino acids
Bower, Justin F.,Jumnah, Roshan,Williams, Andrew C.,Williams, Jonathan M. J.
, p. 1411 - 1420 (2007/10/03)
Methodology has been established for the formation of enantiomerically enriched α-amino acids using palladium-catalysed allylic amination. The formation of enantiomerically enriched allylamines has been achieved with high enantioselectivity. Oxidative cleavage of the allylamines provides arylglycine and glutamic acid derivatives. Additionally, enantiomerically enriched β-amino acids have been prepared in high enantiomeric excess. Palladium-catalysed asymmetric allylic substitution is used as the key synthetic transformation.