136982-36-0 Usage
General Description
3-[(2-Methoxybenzyl)amino]-2-phenyl-piperidine, also known as 2-MeO-Diphenidine, is a chemical compound that belongs to the class of piperidine derivatives. It is a psychoactive drug with sedative and dissociative effects and is often used as a research chemical. The compound acts as a selective NMDA receptor antagonist, meaning it blocks the activity of the N-methyl-D-aspartate (NMDA) receptor. This can result in altered perception, feelings of detachment from reality, and hallucinations. Due to its psychoactive effects, 2-MeO-Diphenidine is considered a controlled substance in many countries and is illegal to possess or distribute without proper authorization. Research on this chemical is ongoing to understand its potential medical and therapeutic applications, as well as its potential for misuse and abuse.
Check Digit Verification of cas no
The CAS Registry Mumber 136982-36-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,9,8 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 136982-36:
(8*1)+(7*3)+(6*6)+(5*9)+(4*8)+(3*2)+(2*3)+(1*6)=160
160 % 10 = 0
So 136982-36-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H24N2O/c1-22-18-12-6-5-10-16(18)14-21-17-11-7-13-20-19(17)15-8-3-2-4-9-15/h2-6,8-10,12,17,19-21H,7,11,13-14H2,1H3
136982-36-0Relevant articles and documents
Sulfinimine-derived 2,3-diamino esters in the asymmetric synthesis of piperidine (2S,3S)-(+)-CP-99,994
Davis, Franklin A.,Zhang, Yanfeng,Li, Danyang
, p. 7838 - 7840 (2007)
Sulfinimine-derived, differentially protected, 2,3-diamino esters are useful building blocks for the asymmetric synthesis of heterocycles and is illustrated by an efficient synthesis of amino piperidine (+)-CP-99,994.
Asymmetric Synthesis of CP-99,994 by Ring-expanding Amination of Monosubstituted Prolinols
Yamagiwa, Noriyuki,Watanuki, Sayaka,Nishina, Takahiro,Suto, Yutaka,Iwasaki, Genji
, p. 54 - 56 (2016/01/20)
A stereospecific synthesis of the biologically active compound (+)-CP-99,994 was achieved. The key step in this process was a ring-expansion rearrangement, in which threo-fused monosubstituted prolinol was effectively transformed to 2,3- disubstituted pip
Synthesis of (+)-L-733,060, (+)-CP-99,994 and (2S,3R)-3-hydroxypipecolic acid: Application of an organocatalytic direct vinylogous aldol reaction
Pansare, Sunil V.,Paul, Eldho K.
experimental part, p. 2119 - 2125 (2012/04/17)
The γ-butenolide obtained from an organocatalyzed, direct vinylogous aldol reaction of γ-crotonolactone and benzaldehyde serves as the key starting material in the expedient synthesis of a 3-hydroxy-2-phenyl piperidine intermediate which is converted to the target 2,3-disubstituted piperidines.
