137-48-4

• 

• Basic information

  1. Product Name: 2-NITROCHLOROBENZENE-4-SULFOMETHYL AMIDE
  2. Synonyms: 2-NITROCHLOROBENZENE-4-SULFOMETHYL AMIDE;4-chloro-N-methyl-3-nitrobenzenesulphonamide;2-Chloro-5-(N-methylsulfamoyl)-nitrobenzene;4-Chloro-N-methyl-3-nitrobenzenesulfonamide;N-Methyl-3-nitro-4-chlorobenzenesulfonamide;(4-Chloro-3-nitrobenzoyl)sulfaMic acid
  3. CAS NO:137-48-4
  4. Molecular Formula: C₇H₇ClN₂O₄S
  5. Molecular Weight: 250.65948
  6. EINECS: 205-296-7
  7. Product Categories: N/A
  8. Mol File: 137-48-4.mol
  9. Article Data: 6

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 392.5°Cat760mmHg
  3. Flash Point: 191.2°C
  4. Appearance: /
  5. Density: 1.53g/cm³
  6. Vapor Pressure: 2.29E-06mmHg at 25°C
  7. Refractive Index: 1.582
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: 2-NITROCHLOROBENZENE-4-SULFOMETHYL AMIDE(CAS DataBase Reference)
  11. NIST Chemistry Reference: 2-NITROCHLOROBENZENE-4-SULFOMETHYL AMIDE(137-48-4)
  12. EPA Substance Registry System: 2-NITROCHLOROBENZENE-4-SULFOMETHYL AMIDE(137-48-4)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 137-48-4(Hazardous Substances Data)

• Suppliers
• Usage
• SDS
• Upstream product
• Downstream Products
• Article

137-48-4 Suppliers

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• 4-chloro-N-methyl-3-nitrobenzenesulphonamide

  Cas No: 137-48-4

• USD $ 3.0-3.0 / Kilogram

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• 2-NITROCHLOROBENZENE-4-SULFOMETHYL AMIDE

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• 2-NITROCHLOROBENZENE-4-SULFOMETHYL AMIDE CAS137-48-4

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• Benzenesulfonamide,4-chloro-N-methyl-3-nitro-

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• Benzenesulfonamide,4-chloro-N-methyl-3-nitro-

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• Benzenesulfonamide,4-chloro-N-methyl-3-nitro-

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• Hangzhou J&H Chemical Co., Ltd.
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• 137-48-4 CAS NO.137-48-4

  Cas No: 137-48-4

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137-48-4 Usage

General Description

2-Nitrochlorobenzene-4-sulfomethyl amide is a chemical compound with the molecular formula C6H5ClN2O5S. It is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is a yellow solid that is soluble in water and organic solvents. The compound is classified as a nitroaromatic compound, which means it has a nitro group attached to an aromatic ring. It is important to handle and store 2-Nitrochlorobenzene-4-sulfomethyl amide with caution, as it is toxic if ingested or inhaled and can cause irritation to the skin and eyes.

Check Digit Verification of cas no

The CAS Registry Mumber 137-48-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 7 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 137-48:
(5*1)+(4*3)+(3*7)+(2*4)+(1*8)=54
54 % 10 = 4
So 137-48-4 is a valid CAS Registry Number.

InChI:InChI=1/C7H7ClN2O4S/c1-9-15(13,14)5-2-3-6(8)7(4-5)10(11)12/h2-4,9H,1H3

137-48-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	4-chloro-N-methyl-3-nitrobenzenesulfonamide

1.2 Other means of identification

Product number	-
Other names	1-Chlor-2-nitro-benzol-4-sulfonsaeure-methylamid

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:137-48-4 SDS

137-48-4Upstream product

• 97-08-5 3-nitro-4-chlorosulfonyl chloride 
• 593-51-1 methylamine hydrochloride 
• 74-89-5 methylamine 

137-48-4Downstream Products

• 1766-16-1 4-Chloro-N-(dichloro-fluoro-methylsulfanyl)-N-methyl-3-nitro-benzenesulfonamide 
• 41607-87-8 3-amino-4-chloro-N-methylbenzenesulfonamide 
• 1351092-89-1 4-chloro-N-methyl-3-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide 
• 1351092-32-4 N-methyl-2-(1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-biphenylsulfonamide 
• 100524-21-8 3-Nitro-4-amino-benzolsulfonsaeure-methylamid 
• 96-58-2 4-hydroxy-N-methyl-3-nitrobenzenesulfonamide 
• 107518-41-2 3-Nitro-4-phenoxy-benzolsulfonsaeure-methylamid 
• 68502-28-3 4-methylamino-3-nitro-benzenesulfonic acid methylamide 
• 93865-70-4 4-p-anisidino-3-nitro-benzenesulfonic acid methylamide 
• 93898-74-9 3-Nitro-4-<4-aethoxy-anilino>-benzolsulfonsaeure-methylamid 
• 101113-23-9 3-Nitro-4-(2,5-dimethyl-phenylmercapto)-benzolsulfonsaeure-methylamid 
• 43041-72-1 4-(dimethylamino)-N-methyl-3-nitrobenzene-1-sulfonamide 
• 106840-39-5 N-methyl-4-(methyloxy)-3-nitrobenzenesulfonamide 
• 100375-34-6 3-Nitro-4-(4-chlor-phenylmercapto)-benzolsulfonsaeure-methylamid 

137-48-4Relevant articles and documents

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

Hofmans, Sam,Berghe, Tom Vanden,Devisscher, Lars,Hassannia, Behrouz,Lyssens, Sophie,Joossens, Jurgen,Van Der Veken, Pieter,Vandenabeele, Peter,Augustyns, Koen

, p. 2041 - 2053 (2016)

Ferroptosis is a nonapoptotic, iron-catalyzed form of regulated necrosis that is critically dependent on glutathione peroxidase 4 (GPX4). It has been shown to contribute to liver and kidney ischemia reperfusion injury in mice. A chemical inhibitor discovered by high-throughput screening displayed inhibition of ferroptosis with nanomolar activity and was dubbed ferrostatin-1 (fer-1). Ferrostatins inhibit oxidative lipid damage, but suffer from inherent stability problems due to the presence of an ester moiety. This limits the application of these molecules in vivo, due to rapid hydrolysis of the ester into the inactive carboxylic acid. Previous studies highlighted the importance of the ethyl ester and suggested steric modifications of the ester for generating improved molecules. In this study, we report the synthesis of novel ferroptosis inhibitors containing amide and sulfonamide moieties with improved stability, single digit nanomolar antiferroptotic activity, and good ADME properties suitable for application in in vivo disease models.

COMPOUNDS AND METHODS

-

Page/Page column 63-64, (2011/12/14)

Disclosed are compounds having the Formula (I), wherein X, Y, Z, R1, R2 and R3 are as defined herein, and methods of making and using the same.

COMPOUNDS AND METHODS

-

Page/Page column 61, (2011/08/04)

Disclosed are compounds having the formula (I): wherein R1, R2, R3, R4, R5, and R6 are as defined herein, and methods of making and using the same.

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