137031-56-2Relevant articles and documents
Litebamine N-homologues: Preparation and anti-acetylcholinesterase activity
Chiou, Chi-Ming,Kang, Jaw-Jou,Lee, Shoei-Sheng
, p. 46 - 50 (1998)
Litebamine N-homologues were easily prepared from laurolitsine, generally via three reaction steps (N-alkylation, solvolysis with 1 M NH4OAc under reflux, and the Mannich reaction) in more than 80% overall yield. Among the prepared compounds, N-propyl-, N-isobutyl-, and N-isopropylnorlitebamines exhibited moderate antiacetylcholinesterase activity (IC50 ca. 7.0 μM), while the corresponding N-metho salt of N-propylnorlitebamine showed potent activity (IC50 2.70 μM).
First total syntheses of the 1,2,3,4-tetrahydronaphtho[2,1-f]isoquinolines annoretine and litebamine
Pampín, M. Carme,Estévez, Juan C.,Estévez, Ramón J.,Suau, Rafael,Castedo, Luis
, p. 8057 - 8065 (2007/10/03)
We describe here the first total synthesis of the two natural 1,2,3,4-tetrahydronaphtho[2,1-f]isoquinolines, annoretine and litebamine, from [2-(2-styrylphenyl)ethyl]methylcarbamic acid ethyl esters. The key steps were the Bischler-Napieralski cyclization
A facile semisynthesis of litEbamine, a novel phenanthrene alkaloid, from boldine via a biogenetical approach
Lee,Lin,Chen,Wu,Chen
, p. 6309 - 6310 (2007/10/02)
Litebamine was semisynthesized from boldine via a biogenetical approach. Main reactions include Von Braun reaction, exhaustive benzylation and Hofmann degradation in one pot, and the Mannich reaction.
