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137553-48-1

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137553-48-1 Usage

General Description

4-AMINO-5-FLUOROQUINAZOLINE is a chemical compound with the molecular formula C8H6N4F. It is a fluorinated quinazoline derivative, which is a type of heterocyclic compound. This chemical is used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical drugs. It has potential applications in the development of anti-cancer, anti-bacterial, and anti-inflammatory drugs. The fluorine substitution in the quinazoline structure can lead to improved drug-like properties, such as increased metabolic stability and enhanced binding affinity to target proteins. Additionally, 4-AMINO-5-FLUOROQUINAZOLINE may also have potential uses in other industries, such as in the development of agrochemicals or materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 137553-48-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,5,5 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 137553-48:
(8*1)+(7*3)+(6*7)+(5*5)+(4*5)+(3*3)+(2*4)+(1*8)=141
141 % 10 = 1
So 137553-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H6FN3/c9-5-2-1-3-6-7(5)8(10)12-4-11-6/h1-4H,(H2,10,11,12)

137553-48-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Fluoroquinazolin-4-amine

1.2 Other means of identification

Product number -
Other names 5-fluoroquinazolin-4-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:137553-48-1 SDS

137553-48-1Downstream Products

137553-48-1Relevant articles and documents

Further Studies on the Synthesis of Quinazolines from 2-Fluorobenzonitriles

Hynes, John B.,Tomazic, Alenka,Parrish, Christie A.,Fetzer, Oliver S.

, p. 1357 - 1364 (2007/10/02)

Recently, we reported that appropriately substituted 2-fluorobenzonitriles undergo cyclization with guanidine carbonate to afford 2,4-diaminoquinazolines usually in good to excellent yield.This paper describes the preparation of a variety of new 2,4-diaminoquinazolines substituted at positions five or seven.In addition, the reactions of selected 2-fluorobenzonitriles with formamidine acetate or acetamidine acetate were examined.The results obtained demonstrate that the analogous 4-amino- and 2-methyl-4-aminoquinazolines can be prepared by this approach but that yields are considerably lower than when guanidine carbonate is employed as the cyclization reagent.

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