138879-88-6Relevant articles and documents
Convenient synthesis of D-threo-[dichloroacetyl 1-14C] chloramphenicol
Sontakke,Patil,Unny,Sivaprasad
, p. 597 - 604 (2005)
A convenient synthesis of chloramphenicol labelled with carbon-14 in the dichloroacetyl group at the 1 position is described. It was prepared as part of a 4-step sequence from [1-14C] glycine and the product was purified by preparative HPLC. A radiochemical yield of 47% was obtained based on [1- 14C] glycine and the product had a specific activity of 0.47 mCi/mmol. The procedure can be employed for the synthesis of high specific activity [14C] chloramphenicol, labelled at 1, 2 or both the positions of dichloroacetyl group. Copyright