138900-22-8 Usage
Description
5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOLE is an organic compound characterized by its light yellow to light orange solid appearance. It is a derivative of indole, a heterocyclic aromatic organic compound that is part of the tryptophan family. The specific chloro and fluoro substitutions on the phenyl ring of this compound give it unique chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOLE is used as a key intermediate compound for the preparation of serotoninergic S2 antagonists. These antagonists are important in the development of medications targeting various conditions related to the serotonin receptor, such as migraines, depression, and other neurological disorders. The compound's unique structure allows it to interact with the serotonin receptor, potentially modulating its activity and providing therapeutic benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 138900-22-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,9,0 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 138900-22:
(8*1)+(7*3)+(6*8)+(5*9)+(4*0)+(3*0)+(2*2)+(1*2)=128
128 % 10 = 8
So 138900-22-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H9ClFN/c15-11-1-6-14-10(9-11)7-8-17(14)13-4-2-12(16)3-5-13/h1-9H
138900-22-8Relevant articles and documents
Identification and synthesis of impurities formed during sertindole preparation
Sunil Kumar,Anjaneyulu,Hima Bindu
supporting information; scheme or table, p. 29 - 33 (2011/03/22)
Sertindole (1), an atypical anti-psychotic drug is used for the treatment of schizophrenia. During the laboratory optimization and later during its bulk synthesis the formation of various impurities was observed. The impurities formed were monitored and t
Process for the preparation of 5-chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indole and method of manufacturing sertindole
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Example 4, (2010/01/31)
A process of manufacturing sertindole comprising reacting 5-chloro-1-(4-fluorophenyl)indole with 4-piperidone in a mixture of an acetic acid and concentrated HCl; reduction of the resulting 5-chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indole and reaction of this compound with 1-(2-chloroethyl)-2-imidazolidinon in order to obtain sertindole.