139115-92-7Relevant articles and documents
Design, synthesis, and biological evaluation of biotin-labeled (-)-ternatin, a potent fat-accumulation inhibitor against 3T3-L1 adipocytes
Shimokawa, Kenichiro,Yamada, Kaoru,Ohno, Osamu,Oba, Yuichi,Uemura, Daisuke
, p. 92 - 95 (2009)
The design, synthesis, and biological activity of biotin-labeled (-)-ternatin are reported. Chemical modification, that is, biotinylation, was conducted using Click chemistry at the 6-position (NMe-d-ProGly moiety), which was a plausible location selected
EXPANSION MICROSCOPY COMPATIBLE ANCHORABLE HandE STAINING FOR HISTOPATHOLOGY
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, (2022/03/18)
The present invention employs the technique for expansion microscopy (E×M) utilizing anchorable derivatives of hematoxylin and eosin (HandE) stained tissue specimens within tissue samples, in order to achieve high resolution detection of biomolecules with precise morphological features of cells and nuclei, which in turn, allows for effective for accurate early stage disease diagnosis including various cancers. Staining with HandE employs anchorable derivatives that can be cross-linked into the E×M hydrogel matrix.
Small molecule compound based on EZH2 protein degradation, and application thereof
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Paragraph 0103-0106, (2021/08/07)
The invention discloses a series of small molecule compounds capable of selectively degrading EZH2 protein, and application thereof. The compounds can be prepared into proper pharmaceutical dosage forms for EZH2-mediated related tumor treatment.
Heterocyclic compound and application thereof
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Paragraph 1323-1327, (2021/08/07)
The invention discloses a heterocyclic compound and application thereof. The invention provides a heterocyclic compound as shown in a formula I, or pharmaceutically acceptable salt thereof. The heterocyclic compound can be used for degrading ALK, c-Met and ROS proteins.
