139525-77-2Relevant articles and documents
PROCESS FOR THE PREPARATION OF AGOMELATINE IN CRYSTALLINE FORM
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Page/Page column 41, (2019/05/02)
The present invention pertains to a process for the preparation of polymorph form X of agomelatine, which comprises providing agomelatine, and crystallizing agomelatine in the presence of at least one of an acid and a salt thereof, and to a polymorph form of agomelatine.
Preparation method of Agomelatine
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Paragraph 0022-0033, (2017/08/30)
The invention relates to a preparation method of Agomelatine. The preparation method comprises the steps of directly reducing a raw material 4-methylbenzenesulfonic acid 1-(cyano methyl)-7-methoxynaphthalene-2-estoral into 2-(7-methoxyl-1-naphthyl) ethylamine, and then further transforming into the Agomelatine. The preparation method of the Agomelatine provided by the invention is less in reaction step, high in yield/purity, and simple in aftertreatment.
A NOVEL PROCESS FOR THE PREPARATION OF TETRALIN AND NAPHTHALENE DERIVATIVES
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, (2015/01/16)
The present invention relates to a novel process for the preparation or tetralin and naphthalene derivatives, including Agomelatine and pharmaceutical acceptable salts thereof. Such compounds are considered to be interesting either as useful building blocks or due to their biological activity.