13997-69-8 Usage
Description
N-(4-bromophenyl)prop-2-enamide, also known as 4-Bromo-N-phenyl-2-butene-1-amide or 4-Bromophenylacrylamide, is a chemical compound with the molecular formula C9H8BrNO. It is an amide derivative of acrylic acid, featuring a phenyl group substituted with a bromine atom and a prop-2-enamide group. N-(4-bromophenyl)prop-2-enamide is recognized for its potential applications in organic synthesis and medicinal chemistry research, particularly as a building block in the synthesis of pharmaceutical compounds. Its structural resemblance to other biologically active compounds has led to studies on its antimalarial and anti-tumor activities, positioning N-(4-bromophenyl)prop-2-enamide as a valuable intermediate in the production of various pharmaceuticals and a promising candidate in the development of new drugs with therapeutic potential.
Uses
Used in Pharmaceutical Industry:
N-(4-bromophenyl)prop-2-enamide is used as a building block for the synthesis of pharmaceutical compounds due to its unique chemical structure and potential to be incorporated into new drug formulations.
Used in Medicinal Chemistry Research:
N-(4-bromophenyl)prop-2-enamide is utilized as a research compound for exploring its antimalarial and anti-tumor activities, given its structural similarities to other biologically active molecules.
Used in Organic Synthesis:
N-(4-bromophenyl)prop-2-enamide is employed as an intermediate in the production of various pharmaceuticals, contributing to the development of new drugs with therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 13997-69-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,9 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 13997-69:
(7*1)+(6*3)+(5*9)+(4*9)+(3*7)+(2*6)+(1*9)=148
148 % 10 = 8
So 13997-69-8 is a valid CAS Registry Number.
13997-69-8Relevant articles and documents
Iridium-Catalyzed Asymmetric Hydroalkenylation of Norbornene Derivatives
Sun, Xin,Bai, Xiao-Yan,Li, An-Zhen,Li, Bi-Jie
supporting information, p. 2182 - 2187 (2021/03/01)
Transition-metal-catalyzed asymmetric hydroalkenylation of alkenes provides an atom-economical method to build molecular complexity from easily available materials. Herein we report an iridium-catalyzed asymmetric hydroalkenylation of unconjugated alkenes with acrylamides and acrylates. The catalytic hydroalkenylation of norbornene derivatives occurred to form products with allylic stereocenters with high chemo-, regio-, and stereoselectivities. DFT calculations revealed that the migratory insertion is irreversible and the enantiodetermination step.
COVALENT TARGETING OF E3 LIGASES
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Paragraph 0591; 0627, (2020/05/19)
Disclosed herein, inter alia, are compositions and methods for targeting E3 ligases. In an aspect is a targeted protein degrader including 1) a targeted protein binder and 2) an E3 Ubiquitin ligase binder, wherein the E3 Ubiquitin ligase is human RNF4 or human RNF114. In an aspect is provided a pharmaceutical composition including a compound as described herein, including embodiments, and a pharmaceutically acceptable excipient.
Metal-Free C–S Bond Cleavage to Access N-Substituted Acrylamide and β-Aminopropanamide
Yang, Ke,Li, Yi,Ma, Zhiyan,Tang, Long,Yin, Yue,Zhang, Hao,Li, Zhengyi,Sun, Xiaoqiang
supporting information, p. 5812 - 5814 (2019/08/27)
Metal-free and Selectfluor-mediated C–S bond cleavage is described. This novel strategy provides a facile and efficient method to access important N-substituted acrylamide and β-aminopropanamide derivatives with good functional group tolerance and yields.
