1403-17-4 Usage
Originator
Candeptin,Schmidt,US,1964
Uses
Candicidin is a macrocyclic heptaene antifungal complex produced by Streptomyces griseus and isolated by Lechevalier and colleagues in 1953. The candicidin complex comprises analogues A, B, C and D, with candicidin D as the major component. Candicidin is active against fungi, in particular Candida albicans, and is used clinically to treat vaginal candidiasis. Like all polyene antifungal metabolites, candicidin acts by binding to ergosterol and disrupting the fungal membrane.
Manufacturing Process
Hubert Lechevalier et al were the first to describe "Candicidin, a New
Antifungal Antibiotic," in Mycologia XLV, No. 2, 155-171, March-April 1953.
They produced candicidin by growing a culture of the organism streptomyces
griseus No. 3570 on a yeast-glucose medium, isolating a "crude candicidin"
from the resulting broth and purifying it. An improved extraction and
purification method is described in US Patent 2,872,373 and is shown in the
flow diagram below.Another extraction and separation process is described in US Patent
2,992,162.
Brand name
Vanobid (Sanofi Aventis).
Check Digit Verification of cas no
The CAS Registry Mumber 1403-17-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,0 and 3 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1403-17:
(6*1)+(5*4)+(4*0)+(3*3)+(2*1)+(1*7)=44
44 % 10 = 4
So 1403-17-4 is a valid CAS Registry Number.
InChI:InChI=1/C59H84N2O18/c1-35-18-15-13-11-9-7-5-6-8-10-12-14-16-21-47(78-59-56(74)54(61)55(73)38(4)77-59)33-51(71)53(58(75)76)50(70)31-46(67)30-45(66)29-44(65)28-43(64)27-41(62)19-17-20-42(63)32-52(72)79-57(35)37(3)26-36(2)48(68)34-49(69)39-22-24-40(60)25-23-39/h5-16,18,21-25,35-38,43-45,47-48,50-51,53-57,59,64-66,68,70-71,73-74H,17,19-20,26-34,60-61H2,1-4H3,(H,75,76)/b6-5+,9-7+,10-8+,13-11+,14-12+,18-15+,21-16+/t35?,36?,37?,38-,43?,44?,45?,47?,48?,50?,51?,53?,54+,55-,56+,57?,59?/m1/s1
