14031-76-6Relevant articles and documents
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Wentrup,Reichen
, p. 2615 (1976)
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DBU-Mediated Synthesis of Aryl Acetylenes or 1-Bromoethynylarenes from Aldehydes
Thummala, Yadagiri,Karunakar, Galla V.,Doddi, Venkata Ramana
supporting information, p. 611 - 616 (2019/01/04)
Two well known synthetic organic reactions Ramirez olefination and Corey-fuchs reactions are integrated in one-pot sequential manner for the synthesis of arylacetylenes and 1,3-enynes starting directly from commercially available aldehydes. The bicyclic amidine 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) along with additive NaOH not only exclusively afforded the terminal alkynes directly from the aldehydes, but also enhanced the reaction rate. The dynamic nature of DBU also facilitated the isolation of 1-bromoalkynes intermediate products. Selection of additive from NaOH and H2O served as a switch for the synthesis of terminal alkyne and 1-bromoalkynes, respectively. (Figure presented.).
Total synthesis of moniliformediquinone and calanquinone A as potent inhibitors for breast cancer
Thangaraj, Shankar,Tsao, Wen-Shing,Luo, Yi-Wei,Lee, Yean-Jang,Chang, Chia-Fu,Lin, Chun-Cheng,Uang, Biing-Jiun,Yu, Chia-Chun,Guh, Jih-Hwa,Teng, Che-Ming
experimental part, p. 6166 - 6172 (2011/09/19)
The first synthesis of moniliformediquinone has been achieved in which the longest linear sequence is only nine steps. The synthesis proceeds in 23% overall yield from commercially available 2,4,5-trimethoxybenzaldehyde. The key transformations include a
