14064-61-0Relevant articles and documents
Aluminum(III) hydrogensulfate: An efficient solid acid catalyst for the preparation of 5-substituted 1H-tetrazoles
Sajadi, S. Mohammad,Khalaj, Mehdi,Jamkarani, Sayyed Mohammad Hosseini,Maham, Mehdi,Kashefib, Mehrdad
, p. 3053 - 3059 (2011)
An efficient method for preparation of 5-substituted 1H-tetrazoles via [2+3] cycloaddition of nitriles and sodium azide is reported using aluminum(III) hydrogensulfate as an effective solid acid. This method has the advantages of good yields, simple methodology, and easy workup. Copyright
The microwave-assisted synthesis of 5-substituted 1: H -tetrazoles via [3+2] cycloaddition over a heterogeneous Cu-based catalyst: Application to the preparation of 13N-labelled tetrazoles
Joshi, Sameer M.,Mane, Rasika B.,Pulagam, Krishna R.,Gomez-Vallejo, Vanessa,Llop, Jordi,Rode, Chandrashekhar
, p. 8084 - 8091 (2017)
The [3+2] cycloaddition between various nitriles and sodium azide proceeds smoothly in the presence of a new CuII catalyst in N-methyl-2-pyrrolidone (NMP) to give the corresponding 5-substituted 1H-tetrazoles. The desired tetrazoles were obtain
Amberlyst-15 catalyzed synthesis of 5-substituted 1-H-tetrazole via [3+2] cycloaddition of nitriles and sodium azide
Shelkar, Radheshyam,Singh, Abhilash,Nagarkar, Jayashree
, p. 106 - 109 (2013)
A mild and efficient method for the preparation of 5-substituted 1-H-tetrazole derivatives is reported using solid acidic resin Amberlyst-15 as an effective heterogeneous catalyst. This method is advantageous because of non-toxicity and stability of catalyst, high product yield, simple methodology, and easy work up. The catalyst was recovered by simple filtration and reused several times delivering moderate to good product yield.
An experimental and computational assessment of acid-catalyzed azide-nitrile cycloadditions
Cantillo, David,Gutmann, Bernhard,Kappe, C. Oliver
, p. 10882 - 10890 (2012)
The mechanism of the azidea-nitrile cycloaddition mediated by different Bronsted and Lewis acids has been addressed through DFT calculations. In all cases activation of the nitrile substrate by the Bronsted or Lewis acid catalyst was found to be responsib
Synthesis, molecular docking and xanthine oxidase inhibitory activity of 5-aryl-1H-tetrazoles
Fatima, Itrat,Zafar, Humaira,Khan, Khalid Mohammed,Saad, Syed Muhammad,Javaid, Sumaira,Perveen, Shahnaz,Choudhary, M. Iqbal
, p. 201 - 211 (2018/05/24)
5-Aryl-1H-tetrazoles (1–24) were synthesized and screened for their xanthine oxidase (XO) inhibitory activity using allopurinol as standard inhibitor (IC50 = 2.0 ± 0.01 μM). Six compounds 3, 4, 5, 9, 21, and 24 exhibited significant to weak act
Choline chloride–ZnCl2: Recyclable and efficient deep eutectic solvent for the [2+3] cycloaddition reaction of organic nitriles with sodium azide
Padvi, Swapnil A.,Dalal, Dipak S.
supporting information, p. 779 - 787 (2017/04/06)
Herein we report first time choline chloride–zinc chloride based deep eutectic solvent is a green and efficient reaction medium for the [2+3] cycloaddition reaction of organic nitriles with sodium azide to afford the corresponding 5-substituted 1H-tetrazo
