14072-67-4Relevant articles and documents
Meyer,Hauser
, p. 3696,3698 (1961)
Method for synthesizing alpha-alkylarylacetamide
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Paragraph 0076; 0077; 0078; 0079; 0080, (2017/06/02)
The invention discloses a method for synthesizing alpha-alkylarylacetamide. In a reaction vessel, aromatic acetonitrile, compound alcohol, a transition metal catalyst metal rhodium complex, alkali, a phosphine ligand and an organic solvent are added; the reaction mixture is subjected to a reaction under a temperature of 130 DEG C in a microwave reactor or under magnetic stirring; the mixture is cooled to room temperature, and is processed through column separation, such that a target compound is obtained. According to the invention, nitrile and alcohol are adopted as initial raw materials; under the participation of the transition metal catalyst, the phosphine ligand and alkali, alpha-alkylarylacetamide is directly synthesized. The reaction has three significant advantages: (1) commercialized or easy-to-prepare nitrile and almost nontoxic alcohol are adopted as initial raw materials; and (2) the reaction has high atomic economy. Therefore, the reaction meets the requirements of green chemistry, and has a good development prospect.
Selective hydrolysis of nitriles to amides using NaOH-PEG under microwave irradiation
Bendale, Pravin M.,Khadilkar, Bhushan M.
, p. 1713 - 1718 (2007/10/03)
We describe here an efficient, rapid and selective method for the conversion of nitriles in to their corresponding amides in the presence of PEG-400, aqueous sodium hydroxide system under microwave irradiation.
