142187-88-0

• 

• Basic information

  1. Product Name: 9-(4,5-bishydroxymethylcyclopent-2-en-1-yl)-9H-adenine
  2. Synonyms: 9-(4,5-bishydroxymethylcyclopent-2-en-1-yl)-9H-adenine
  3. CAS NO:142187-88-0
  4. Molecular Formula: C12H15 N5 O2
  5. Molecular Weight: 0
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 142187-88-0.mol
  9. Article Data: 5

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 556.2°Cat760mmHg
  3. Flash Point: 290.2°C
  4. Appearance: /
  5. Density: 1.66g/cm³
  6. Vapor Pressure: 3.32E-13mmHg at 25°C
  7. Refractive Index: 1.8
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: 9-(4,5-bishydroxymethylcyclopent-2-en-1-yl)-9H-adenine(CAS DataBase Reference)
  11. NIST Chemistry Reference: 9-(4,5-bishydroxymethylcyclopent-2-en-1-yl)-9H-adenine(142187-88-0)
  12. EPA Substance Registry System: 9-(4,5-bishydroxymethylcyclopent-2-en-1-yl)-9H-adenine(142187-88-0)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 142187-88-0(Hazardous Substances Data)

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142187-88-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 142187-88-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,1,8 and 7 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 142187-88:
(8*1)+(7*4)+(6*2)+(5*1)+(4*8)+(3*7)+(2*8)+(1*8)=130
130 % 10 = 0
So 142187-88-0 is a valid CAS Registry Number.

InChI:InChI=1/C12H15N5O2/c13-11-10-12(15-5-14-11)17(6-16-10)9-2-1-7(3-18)8(9)4-19/h1-2,5-9,18-19H,3-4H2,(H2,13,14,15)/t7-,8-,9-/m0/s1

142187-88-0Upstream product

• 182689-67-4 ((1R,4S,5S)-4,5-Bis-methoxymethoxymethyl-cyclopent-2-enyl)-methanol 
• 140440-30-8 7-syn-<(benzyloxy)methyl>-2-azabicyclo<2.2.1>hept-5-en-3-one 
• 140440-37-5 (+/-)-9-<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>-6-chloropurine 
• 140440-36-4 (+/-)-5-amino-4-<<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>amino>-6-chloropyrimidine 
• 140440-33-1 7-syn-<(benzyloxy)methyl>-2-(ethoxycarbonyl)-2-azabicyclo<2.2.1>hept-5-en-3-one 
• 140440-34-2 ethyl (+/-)-N-<5α-<(benzyloxy)methyl>-4β-(hydroxymethyl)cyclopent-2-en-1β-yl>carbamate 
• 140440-35-3 (+/-)-5α-<(benzyloxy)methyl>-4β-(hydroxymethyl)cyclopent-2-en-1β-ylamine 
• 117624-93-8 (3aS,4R,5S,6aR)-5-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-hexahydro-cyclopenta[b]furan-2-one 
• 143833-71-0 (1R,2S,3R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-hydroxy-ethyl)-cyclopentanol 
• 143833-75-4 Acetic acid (1R,2S,3R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(6-chloro-purin-9-yl)-cyclopentylmethyl ester 
• 143833-73-2 9-[(1R,2R,3S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-vinyl-cyclopentyl]-6-chloro-9H-purine 
• 143833-74-3 [(1R,2S,3R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(6-chloro-purin-9-yl)-cyclopentyl]-methanol 
• 143833-78-7 Acetic acid (1R,2S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(6-chloro-purin-9-yl)-cyclopent-3-enylmethyl ester 
• 143833-77-6 Acetic acid (1R,2S,3R,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(6-chloro-purin-9-yl)-3-hydroxy-cyclopentylmethyl ester 

142187-88-0Downstream Products

142187-88-0Relevant articles and documents

Synthesis of nucleosides and related compounds. XXXI. Resolution of 9-[c- 4, t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine [(±)-BCA] by means of high-pressure-mediated deamination with adenosine deaminase

Katagiri,Shiraishi,Toyota,Sato,Kaneko,Aikawa

, p. 1027 - 1029 (1993)

Deamination of an anti-human immunodeficiency virus (anti-HIV) carbocyclic adenine nucleoside, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H- adenine (BCA) by adenosine deaminase under a variety of pressures (1 bar- 6kbar) was investigated. It was found that, while (+)-BCA was practically unaffected, the deamination of (-)-BCA was remarkably enhanced under 4 kbar to give the corresponding (-)-hypoxanthine derivative [(-)-BCH)] in nearly 100% ee.

Synthesis and anti-HIV activity of 9-[e-4,t-5-bis(hydroxymethyl)cyclopent- 2-en-r-1-yl]-9H-adenine

Katagiri,Nomura,Sato,Kaneko,Yusa,Tsuruo

, p. 1882 - 1886 (2007/10/02)

The synthesis and in vitro anti-HIV activity of two new racemic nucleoside analogues are described; namely, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en- r-1-yl]-9H-adenine (12) and its guanine analogue 18. While the latter (18) showed no activity, the therapeutic index of the former (12) was 200 and comparable to that (400) of carbovir. One enantiomer of 12 may be viewed as an analogue of carbocyclic oxetanocin and the other as an analogue of carbovir. Hence, these results indicate that one or both of the individual enantiomers of 12 could serve as candidates or lead compounds for the development of anti-AIDS agents.

A NOVEL AND EFFICIENT SYNTHESIS OF 9-(c-4,t-5-BISHYDROXYMETHYLCYCLOPENT-2-EN-r-1-YL)-9H-ADENINE (BCA) HAVING ANTI-HIV ACTIVITY FROM NORBORNADIENE

Katagiri, Nobuya,Sato, Hiroshi,Arai, Sachie,Toyota, Akemi,Kaneko, Chikara

, p. 1097 - 1100 (2007/10/02)

9-(c-4, t-5-Bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine (BCA: 1), a novel carboxylic nucleoside having significant anti-HIV activity, has been synthesized from norbornadiene.

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