142773-73-7 Usage
Description
(2'S,3S)-1-(2-METHYLAMINO-2-PHENYL-ETHYL)-PYRROLIDIN-3-OL, with the CAS number 142773-73-7, is a complex organic compound characterized by its unique molecular structure. It is a chiral molecule with specific stereochemistry at the 2' and 3S positions, which plays a crucial role in its reactivity and potential applications.
Uses
Used in Pharmaceutical Industry:
(2'S,3S)-1-(2-METHYLAMINO-2-PHENYL-ETHYL)-PYRROLIDIN-3-OL is used as a reagent for the preparation of novel heterobicyclic compounds. These compounds serve as kappa opioid receptor agonists, which are significant in the development of medications targeting pain management and other therapeutic applications related to the opioid system.
The compound's specific stereochemistry and reactivity make it a valuable building block in the synthesis of complex pharmaceutical agents. Its use in the preparation of heterobicyclic compounds highlights its potential role in advancing drug discovery and development, particularly in the area of pain management and treatment of opioid-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 142773-73-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,7,7 and 3 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 142773-73:
(8*1)+(7*4)+(6*2)+(5*7)+(4*7)+(3*3)+(2*7)+(1*3)=137
137 % 10 = 7
So 142773-73-7 is a valid CAS Registry Number.
142773-73-7Relevant articles and documents
NOVEL HETEROBICYCLIC COMPOUNDS AS KAPPA OPIOID AGONISTS
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Page/Page column 25, (2015/09/22)
The present invention relates to novel compounds of the general formula (I), which are selective and peripherally acting KOR agonist, their tautomeric forms, their enantiomers, their diastereoisomers, their stereoisomers, their pharmaceutically accepted salts, or prodrugs thereof which are useful in the treatment or prevention of diseases in which" the Kappa (κ) opioid receptors (KOR) are involved, such as treatment or prevention of visceral pain, hyperalgesia, rheumatoid arthritic inflammation, osteoarthritic inflammation, IBD inflammation, IBS inflammation, ocular inflammation, otitic inflammation or autoimmune inflammation. The invention also relates to process for the manufacture of said compounds, and pharmaceutical compositions containing them and their use.
Method for producing enantiomer-free N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrolidine-1-yl)ethyl]-2,2-diphenylacetamide
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Example 4, (2008/06/13)
The invention relates to a novel process for the alternative preparation of N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamide or N-methyl-N-[(1R)-1-phenyl-2-((3R)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamide, and the novel compounds N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethane] and N-methyl-N[(1R)-1-phenyl-2-((3R)-3-hydroxypyrrolidin-1-yl) ethane], which are prepared as intermediates.
