143797-63-1

• 

• Basic information

  1. Product Name: SB 200646 HYDROCHLORIDE
  2. Synonyms: SB 200646 HYDROCHLORIDE;N-(1-METHYL-1H-5-INDOLYL)-N'-(3-PYRIDINYL)UREA HYDROCHLORIDE;N-(1-METHYL-1H-INDOL-5-YL)-N'-3-PYRIDINYLUREA HYDROCHLORIDE;SB200646HCl;N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea;N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea;SB 200646;1-(1-Methyl-1H-indol-5-yl)-3-pyridin-3-yl-urea
  3. CAS NO:143797-63-1
  4. Molecular Formula: C15H15ClN4O
  5. Molecular Weight: 302.76
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 143797-63-1.mol
  9. Article Data: 3

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 390.9°Cat760mmHg
  3. Flash Point: 190.2°C
  4. Appearance: pale yellow/solid
  5. Density: 1.26g/cm³
  6. Vapor Pressure: 2.57E-06mmHg at 25°C
  7. Refractive Index: N/A
  8. Storage Temp.: 2-8°C
  9. Solubility: DMSO: ~26 mg/mL, soluble
  10. CAS DataBase Reference: SB 200646 HYDROCHLORIDE(CAS DataBase Reference)
  11. NIST Chemistry Reference: SB 200646 HYDROCHLORIDE(143797-63-1)
  12. EPA Substance Registry System: SB 200646 HYDROCHLORIDE(143797-63-1)

• Safety Data

  1. Hazard Codes: Xi
  2. Statements: 36/37/38
  3. Safety Statements: 26-36
  4. WGK Germany: 3
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 143797-63-1(Hazardous Substances Data)

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• Urea,N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl-

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• Urea,N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl-

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• SB 200646 hydrochloride;N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea

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• Wuxi Morality Chemical Co., Ltd
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143797-63-1 Usage

Biological Activity

5-HT 2C/2B receptor antagonist, selective over 5-HT 1A . Affinities are 7.4 (pA 2 ), 6.9 (pK i ) and 5.2 (pK i ) for 5-HT 2B , 2C and 2A respectively. Orally active in vivo .

Check Digit Verification of cas no

The CAS Registry Mumber 143797-63-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,7,9 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 143797-63:
(8*1)+(7*4)+(6*3)+(5*7)+(4*9)+(3*7)+(2*6)+(1*3)=161
161 % 10 = 1
So 143797-63-1 is a valid CAS Registry Number.

InChI:InChI=1/C15H14N4O.ClH/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13;/h2-10H,1H3,(H2,17,18,20);1H

143797-63-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	1-(1-methylindol-5-yl)-3-pyridin-3-ylurea

1.2 Other means of identification

Product number	-
Other names	Mip-urea

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:143797-63-1 SDS

143797-63-1Upstream product

• 6146-52-7 5-nitroindole 
• 29906-67-0 1-methyl-5-nitro-1H-indole 
• 102308-97-4 1-methyl-1H-indol-5-amine 
• 15268-31-2 3-Pyridyl isocyanate 

143797-63-1Downstream Products

143797-63-1Relevant articles and documents

Model studies on a synthetically facile series of N-substituted phenyl-N'-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT(2C/2B) receptor antagonists

Bromidge, Steven M.,Dabbs, Steven,Davies, David T.,Davies, Susannah,Duckworth, D.Malcolm,Forbes, Ian T.,Gadre, Angela,Ham, Peter,Jones, Graham E.,King, Frank D.,Saunders, Damian V.,Thewlis, Kevin M.,Vyas, Deepa,Blackburn, Thomas P.,Holland, Vicky,Kennett, Guy A.,Riley, Graham J.,Wood, Martyn D.

, p. 2767 - 2773 (2007/10/03)

A model series of 5-HT(2C) antagonists have been prepared by rapid parallel synthesis. These N-substituted phenyl-N'-pyridin-3-yl ureas were found to have a range of 5-HT(2C) receptor affinities and selectivities over the closely related 5-HT(2A) receptor. Extrapolation of simple SAR, derived from this set of compounds, to the more active but synthetically more complex 1-(3-pyridyl-carbamoyl)indoline series allowed us to target optimal substitution patterns and identify potent and selective 5-HT(2C/2B) antagonists. Copyright (C) 1999 Elsevier Science Ltd.

N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: The first selective 5-HT(1C) receptor antagonist

Forbes,Kennett,Gadre,Ham,Hayward,Martin,Thompson,Wood,Baxter,Glen,Murphy,Stewart,Blackburn

, p. 1104 - 1107 (2007/10/02)

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