144294-61-1Relevant articles and documents
Parallel synthesis of novel 3-substituted 1-ethyl-6-methylpyrimido[4,5-c] pyridazine-5,7(1H,6H)-dione Analogs
Chen, Yongsheng,Barber, Jack R.,Ng, Shi Chung,Zhou, Yuefen
experimental part, p. 821 - 832 (2010/05/18)
A library of novel 1H-pyrimido[4,5-c]pyridazine-5,7-dione analogs was prepared in a parallel fashion via the cyclization of 6-(1-ethylhydrazinyl)-3- methylpyrimidine-2,4(1H,3H)-dione (4) with-bromoketones and was then isolated by a two-step purification method with 90% purity. Both the library synthesis and purification method proved suitable for analogs with a high diversity of substitution at the 3-position including various alkyl, aryl, and heteroaryl groups.
Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
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Page 9, (2008/06/13)
The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diones, pharmaceutically acceptable salts thereof and physiologically functional derivatives. The invention therefore relates to compounds of the formula I, in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are suitable for use as antidiabetics, for example.
