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1449-05-4

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1449-05-4 Usage

Chemical Properties

Glycyrrhetinic acid is a kind of glycoside composed of glycyrrhizic acid-ff two molecules glucuronic acid. It appears as white crystalline powder with sweet taste. The sweetness is about 200 times of the sucrose. Its sweetness is different from other sweeteners such as sucrose. After eating, you can sense the sweetness only after a few moments but the retention time is long. Combination of a small amount of glycyrrhizin and sucrose can save 20% sucrose without affecting the sweetness. Although having no aroma, it has incense effect. It has a melting point (decomposition) of 220 ° C. The aqueous solution is weakly acidic and can be treated by acid.

Uses

Different sources of media describe the Uses of 1449-05-4 differently. You can refer to the following data:
1. Sweeteners; sweetness improving agents; flavor enhancers (dairy products, cocoa products, egg products, mutton), flavoring agents (function well especially when used in combination with salt), Chinese folk mostly use it in sauce and sauce products, pickled goods and so on.
2. 18α-Glycyrrhetinic acid may be used to synthesize:3-keto-18α-glycyrrhetinic acid methyl esters of 18α-glycyrrhetinic acidmethyl esters of 3-keto-18α-glycyrrhetinic acid

General Description

18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice. It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1). It also shows anti-proliferative and apoptotic effect on hepatic stellate cells (HSCs).

Check Digit Verification of cas no

The CAS Registry Mumber 1449-05-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,4 and 9 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1449-05:
(6*1)+(5*4)+(4*4)+(3*9)+(2*0)+(1*5)=74
74 % 10 = 4
So 1449-05-4 is a valid CAS Registry Number.
InChI:InChI=1/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/p-1/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1

1449-05-4 Well-known Company Product Price

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  • Aldrich

  • (G8503)  18α-Glycyrrhetinicacid  ≥95%

  • 1449-05-4

  • G8503-250MG

  • 720.72CNY

  • Detail
  • Aldrich

  • (G8503)  18α-Glycyrrhetinicacid  ≥95%

  • 1449-05-4

  • G8503-1G

  • 2,343.51CNY

  • Detail

1449-05-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name glycyrrhetinate

1.2 Other means of identification

Product number -
Other names 18a-Glycyrrhetic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1449-05-4 SDS

1449-05-4Synthetic route

methyl 3-benzoyl-18α-glycyrrhetinate
650140-36-6

methyl 3-benzoyl-18α-glycyrrhetinate

18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

Conditions
ConditionsYield
With sodium hydroxide In water; ethylene glycol; isopropyl alcohol for 2h; Heating;84%
18α-glycyrrhizic acid

18α-glycyrrhizic acid

18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

Conditions
ConditionsYield
With hydrogenchloride In water; acetic acid at 100℃; for 1h;72%
enoxolone
471-53-4

enoxolone

18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

Conditions
ConditionsYield
With potassium tert-butylate for 8h; Reagent/catalyst; Reflux;68.5%
With potassium hydroxide In diethylene glycol for 2h; Reflux;46%
With potassium hydroxide In diethylene glycol at 220℃; for 2h;45%
With potassium hydroxide In diethylene glycol at 100 - 220℃;43.7%
With hydrogenchloride; acetic acid
methyl 18α,b-glycyrrhetinate

methyl 18α,b-glycyrrhetinate

18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

Conditions
ConditionsYield
With sodium hydroxide In water; ethylene glycol; isopropyl alcohol for 2h; Heating;20%
Multi-step reaction with 2 steps
1: pyridine / 14 h / 20 °C
2: 84 percent / sodium hydroxide / H2O; propan-2-ol; ethane-1,2-diol / 2 h / Heating
View Scheme
glycyrrhetinoic acid methyl ester

glycyrrhetinoic acid methyl ester

18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

Conditions
ConditionsYield
With potassium hydroxide
18α-glycyrrhizic acid

18α-glycyrrhizic acid

A

18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

B

glycyrrhetic acid 3-O-mono-β-D-glucuronide

glycyrrhetic acid 3-O-mono-β-D-glucuronide

Conditions
ConditionsYield
With β-glucuronidase Kinetics; Reagent/catalyst; Enzymatic reaction;
glycyrrhetic acid 3-O-mono-β-D-glucuronide

glycyrrhetic acid 3-O-mono-β-D-glucuronide

18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

Conditions
ConditionsYield
With β-glucuronidase for 10h; Enzymatic reaction;
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

(3β,18α)-methyl 3-hydroxy-11-oxoolean-12-30-oate
5092-01-3

(3β,18α)-methyl 3-hydroxy-11-oxoolean-12-30-oate

Conditions
ConditionsYield
In diethyl ether100%
In diethyl ether; dichloromethane76.3%
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

methyl iodide
74-88-4

methyl iodide

(3β,18α)-methyl 3-hydroxy-11-oxoolean-12-30-oate
5092-01-3

(3β,18α)-methyl 3-hydroxy-11-oxoolean-12-30-oate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 2h;86%
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

diazodiphenylmethane
908093-98-1

diazodiphenylmethane

(3β,18α,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid diphenylmethyl ester
441759-67-7

(3β,18α,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid diphenylmethyl ester

Conditions
ConditionsYield
In methanol; diethyl ether at 45℃;84%
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

3,11-dioxo-18α-olean-12-en-30-oic acid
6184-16-3

3,11-dioxo-18α-olean-12-en-30-oic acid

Conditions
ConditionsYield
With chromium trioxide-pyridine complex In dichloromethane at 20℃; for 1h;80%
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride
251105-80-3

N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride

(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bS)-10-hydroxy-N-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamide

(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bS)-10-hydroxy-N-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamide

Conditions
ConditionsYield
Stage #1: 18-α-glycyrrhetinic acid; N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 1.16667h; Inert atmosphere;
Stage #2: With dmap at 20℃; for 11h; Inert atmosphere;
69%
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide
159005-71-7

N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide

(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bS)-10-hydroxy-N-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamide

(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bS)-10-hydroxy-N-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamide

Conditions
ConditionsYield
Stage #1: 18-α-glycyrrhetinic acid; N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 1.16667h; Inert atmosphere;
Stage #2: With dmap at 20℃; for 11h; Inert atmosphere;
65%
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide
169280-56-2

4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide

(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bS)-N-((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamide

(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bS)-N-((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamide

Conditions
ConditionsYield
Stage #1: 18-α-glycyrrhetinic acid; 4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 1.16667h; Inert atmosphere;
Stage #2: With dmap at 20℃; for 11h; Inert atmosphere;
65%
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

(3β,18α)-methyl 3-hydroxy-11-oxoolean-12-30-oate
5092-01-3

(3β,18α)-methyl 3-hydroxy-11-oxoolean-12-30-oate

Conditions
ConditionsYield
With diazomethane; methanol; diethyl ether
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

acetic anhydride
108-24-7

acetic anhydride

3β-acetoxy-11-oxo-18α-oleanen-(12)-oic acid-(30)
18305-96-9

3β-acetoxy-11-oxo-18α-oleanen-(12)-oic acid-(30)

Conditions
ConditionsYield
With pyridine
succinic acid anhydride
108-30-5

succinic acid anhydride

18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

Methyl 3-O-(β-carboxypropionyl)-18α-glycyrrhetat
17175-23-4

Methyl 3-O-(β-carboxypropionyl)-18α-glycyrrhetat

Conditions
ConditionsYield
(i) MeOH, Et2O, (ii) /BRN= 108441/, Py; Multistep reaction;
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

11-oxo-18α-olean-12-ene-3β,30-diol
60209-40-7

11-oxo-18α-olean-12-ene-3β,30-diol

Conditions
ConditionsYield
With manganese(IV) oxide; lithium aluminium tetrahydride 1.) THF, 60 deg C, 1 h, 2.) CHCl3, THF, 25 h; Yield given. Multistep reaction;
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

(18α)-methyl 3,11-dioxoolean-12-en-30-oate
6588-91-6

(18α)-methyl 3,11-dioxoolean-12-en-30-oate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / CrO3-Py / CH2Cl2 / 1 h / 20 °C
2: 100 percent / diethyl ether
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 25 °C
View Scheme
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

methyl β-D-galactopyranosyl-(1->4)-β-D-glucopyranosyl-3-O-18α-glycyrrhetinate

methyl β-D-galactopyranosyl-(1->4)-β-D-glucopyranosyl-3-O-18α-glycyrrhetinate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 31.1 percent / Ag2O; I2 / CHCl3 / 48 h / 20 °C
2: 405 mg / sodium methylate / CHCl3 / 1.5 h / -20 °C
3: 85 mg / H2 / 10 percent Pd/C / methanol / 20 °C / 2587.71 Torr
4: 65.5 percent / diethyl ether; methanol / 1 h
View Scheme
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

β-D-galactopyranosyl-(1->4)-β-D-glucopyranosyl-3-O-18α-glycyrrhetic acid
22596-24-3

β-D-galactopyranosyl-(1->4)-β-D-glucopyranosyl-3-O-18α-glycyrrhetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 31.1 percent / Ag2O; I2 / CHCl3 / 48 h / 20 °C
2: 405 mg / sodium methylate / CHCl3 / 1.5 h / -20 °C
3: 85 mg / H2 / 10 percent Pd/C / methanol / 20 °C / 2587.71 Torr
View Scheme
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

C55H76O14

C55H76O14

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 31.1 percent / Ag2O; I2 / CHCl3 / 48 h / 20 °C
2: 405 mg / sodium methylate / CHCl3 / 1.5 h / -20 °C
View Scheme
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

diphenylmethyl 2',3',6',2'',3'',4'',6''-heptaacetyl-β-D-galactopyranosyl-(1->4)-β-D-glucopyranosyl-3-O-18α-glycyrrhetinate
441759-70-2

diphenylmethyl 2',3',6',2'',3'',4'',6''-heptaacetyl-β-D-galactopyranosyl-(1->4)-β-D-glucopyranosyl-3-O-18α-glycyrrhetinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 31.1 percent / Ag2O; I2 / CHCl3 / 48 h / 20 °C
View Scheme
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

(3β,18α)-methyl 3-acetoxy-11-oxoolean-12-en-30-oate
10301-82-3

(3β,18α)-methyl 3-acetoxy-11-oxoolean-12-en-30-oate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: diazomethane; diethyl ether
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 25 °C
2: pyridine / dichloromethane / 2 h / 25 °C
View Scheme
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

A

(3α,18α)-methyl 3-amino-11-oxoolean-12-en-30-oate

(3α,18α)-methyl 3-amino-11-oxoolean-12-en-30-oate

B

(3β,18α)-methyl 3-amino-11-oxoolean-12-en-30-oate

(3β,18α)-methyl 3-amino-11-oxoolean-12-en-30-oate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 25 °C
3: ammonium acetate; sodium cyanoborohydride / methanol / 24 h / 25 °C
View Scheme
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

A

(3β)-methyl 3-acetoxy-13-carboxy-19-hydroxy-11-oxo-C-norolean-18-en-30-oate-12,19-lactone

(3β)-methyl 3-acetoxy-13-carboxy-19-hydroxy-11-oxo-C-norolean-18-en-30-oate-12,19-lactone

B

(3β,18β)-3-acetoxy-18-hydroxy-11-oxoolean-12-en-30-oic acid-30,18-lactone

(3β,18β)-3-acetoxy-18-hydroxy-11-oxoolean-12-en-30-oic acid-30,18-lactone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 25 °C
2: pyridine / dichloromethane / 2 h / 25 °C
3: acetic acid; selenium(IV) oxide / 4 h / 145 °C / Microwave irradiation
View Scheme
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

3-ethoxycarbonyl-7-oxabicyclo[2.2.1]heptane-2-carbonyl chloride

3-ethoxycarbonyl-7-oxabicyclo[2.2.1]heptane-2-carbonyl chloride

3β-(2-formyl-7-oxabicyclo[2.2.1]heptane-3-carbethoxy)oxy-18α-glycyrrhetinic acid

3β-(2-formyl-7-oxabicyclo[2.2.1]heptane-3-carbethoxy)oxy-18α-glycyrrhetinic acid

Conditions
ConditionsYield
With dmap In dichloromethane for 10h; Reflux;
[2-(2,6-dichloroanilino)phenyl]acetic acid
15307-86-5

[2-(2,6-dichloroanilino)phenyl]acetic acid

18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

DC

DC

Conditions
ConditionsYield
With pyridine; dmap In dichloromethane at 30℃;
18-α-glycyrrhetinic acid
1449-05-4

18-α-glycyrrhetinic acid

UDP-glucuronic acid
2616-64-0

UDP-glucuronic acid

18α-glycyrrhetinic acid 30-O-β-D-glucoside

18α-glycyrrhetinic acid 30-O-β-D-glucoside

Conditions
ConditionsYield
With recombinant Glycyrrhiza uralensis glycosyltransferase UGT73F17; magnesium(II) In aq. phosphate buffer at 45℃; for 12h; pH=7.5; regiospecific reaction;

1449-05-4Relevant articles and documents

18α-Glycyrrhetinic acid monoglucuronide as an anti-inflammatory agent through suppression of the NF-κB and MAPK signaling pathway

Li, Bo,Yang, Yongan,Chen, Liuzeng,Chen, Shichao,Zhang, Jing,Tang, Wenjian

, p. 1498 - 1504 (2017)

Based on the SAR analysis of glycyrrhizin, 18α-glycyrrhetinic acid monoglucuronide (18α-GAMG) with strong inhibition against LPS-induced NO and IL-6 production in RAW264.7 cells was discovered. Western blotting and immunofluorescence results showed that 18α-GAMG reduced the expression of iNOS, COX-2, and MAPKs, as well as activation of NF-κB in the LPS-stimulated RAW264.7 cells. Further in vivo results showed that 18α-GAMG could significantly improve the pathological changes of CCl4-induced hepatic fibrosis.

Glycyrrhetinic acid derivative synthesis and use thereof

-

Paragraph 0021; 0038; 0039, (2017/08/24)

The invention designs and synthetizes a lead compound by using a glycyrrhetinic acid derivative as a carrier and being connected with norcantharidin and a derivative thereof through ester bonds, the obtained lead compound expects to have the advantages of having liver targeting action, prolonging action time, reducing toxic and side effects and improving the curative effect of resisting liver cancer, and a model compound is provided for the research of a liver targeting medicine for the liver cancer. Firstly, two positions of C11 and C30 in glycyrrhetinic acid molecules are reduced and synthetized respectively, methyl ester is chemically modified into glycyrrhetinic acid (GA) and 18 alpha-glycyrrhetinic acid as well as a derivative thereof, the glycyrrhetinic acid (GA) and 18 alpha-glycyrrhetinic acid as well as the derivative thereof are used as framework molecules, through a series of reactions, the framework molecules and the norcantharidin (NCTD) as well as a derivative thereof are condensed to form ester as a prodrug, a cell activity screening test is performed on 5 object compounds, 13 object compounds in 3 series are synthetized, and structural characterization is performed on a carbon spectrum, a hydrogen spectrum and a mass spectrum; the influence of different concentrations of 5 object compounds on HepG2 cell proliferation of the liver cancer is inspected by a method, results show that inhibitory action presents time-dose dependence, and the suppression ratio of 14 mu g/mL is the highest.

Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases

Beseda, Igor,Czollner, Laszlo,Shah, Priti S.,Khunt, Rupesh,Gaware, Rawindra,Kosma, Paul,Stanetty, Christian,Ruiz-Ruiz, Maria Carmen del,Amer, Hassan,Mereiter, Kurt,Cunha, Thierry Da,Odermatt, Alex,Classen-Houben, Dirk,Jordis, Ulrich

experimental part, p. 433 - 454 (2010/03/30)

The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11β-hydroxysteroid dehydrogenase (11β-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.

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