144978-35-8Relevant articles and documents
INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION
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Paragraph 00370-00372, (2021/10/15)
Compounds of Formula (I) and methods of inhibiting the replication of viruses in a biological sample or patient, of reducing the amount of viruses in a biological sample or patient, and of treating a virus infection in a patient, comprising administering to said biological sample or patient an effective amount of a compound represented by Formula (I), a compound of Table A or B or a pharmaceutically acceptable salt thereof.
Preparation method of (s)-1-(t-butyloxycarboryl)-5-oxopyrrolidine-2-carboxylic acid ethyl ester
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Paragraph 0013-0015, (2018/12/13)
The invention discloses a preparation method of (s)-1-(t-butyloxycarboryl)-5-oxopyrrolidine-2-carboxylic acid ethyl ester and aims at mainly solving the technical problems of complexity, long period,high cost, low yield and the like in the original technology. In the technical scheme of the invention, the preparation method comprises the following steps of step 1, preparation of boc-glu-oet: mixing h-glu-oet with a protective agent of boc- groups to prepare the boc-glu-oet, or mixing boc-glu-oh with ethyl acetate, performing reaction on a mixture under the action of diazoalkane, and performing treatment to obtain the boc-glu-oet; step 2, preparation of carboxyl active ester of the boc-glu-oet: mixing the boc-glu-oet with a carboxyl activating reagent, and performing low-temperature reaction on a mixture under the action of condensing agent to prepare a carboxyl activator of the boc-glu-oet; and sep 3, preparation of boc-pyr-oet: performing intramolecular cyclization on the carboxyl activator of the boc-glu-oet to prepare a crude product, and then performing extraction, purification and crystallization to obtain a target product. The preparation method provided by the invention greatly simplifies the process route, lowers the cost and is suitable for mass production.
Proline compounds as Granzyme B inhibitors
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Page/Page column 67, (2016/10/27)
Proline compounds as Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Methods for treating cutaneous scleroderma, epidermolysis bullosa, radiation dermatitis, alopecia areata, and discoid lupus erythematosus are provided.
