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145158-71-0

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145158-71-0 Usage

Uses

Treatment of gastrointestinal motility disorders (selective serotonin 5HT4antagonist).

Indications

Tegaserod (Zelnorm) is serotonin-4 (5-HT4) receptor agonists that stimulate GI motility.

Brand name

Zelmac (Novartis).

Clinical Use

Tegaserod is being developed as a treatment for constipation- predominant irritable bowel syndrome (IBS). Within the first week, patients treated with tegaserod had significant improvements in abdominal pain and discomfort, constipation, and overall well-being. Efficacy was maintained throughout the treatment period. Tegaserod also demonstrated significant improvements in the three bowel-related assessments (stool frequency, stool consistency, and straining) within the first week, and these improvements were sustained throughout the treatment period. The most common adverse events reported thus far are headache and diarrhea.

Check Digit Verification of cas no

The CAS Registry Mumber 145158-71-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,1,5 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 145158-71:
(8*1)+(7*4)+(6*5)+(5*1)+(4*5)+(3*8)+(2*7)+(1*1)=130
130 % 10 = 0
So 145158-71-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H23N5O.C4H4O4/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15;5-3(6)1-2-4(7)8/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b20-11+;2-1+

145158-71-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name tegaserod

1.2 Other means of identification

Product number -
Other names Tegaserode

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:145158-71-0 SDS

145158-71-0Relevant articles and documents

New addition salt of N-amino-N'-pentylguanidine, the process for its preparation and use thereof for obtaining tegaserod

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Page/Page column 3, (2008/12/07)

The present invention refers to a new addition salt of N-amino-N'-pentylguanidine, particularly to the oxalate addition salt of N-amino-N'-pentylguanidine. The process for preparing said oxalate addition salt comprises the steps of: a) reacting the N-amino-N'-pentylguanidine, as a free base or in a salt form, with oxalic acid in a polar medium; and b) recovering the product in a solid form. This addition salt is useful for obtaining the tegaserod free base with a better purity and yield.

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