145158-71-0 Usage
Uses
Treatment of gastrointestinal motility disorders
(selective serotonin 5HT4antagonist).
Indications
Tegaserod (Zelnorm) is serotonin-4 (5-HT4) receptor agonists that stimulate GI motility.
Brand name
Zelmac (Novartis).
Clinical Use
Tegaserod is being developed as a treatment for constipation-
predominant irritable bowel syndrome (IBS).
Within the first week, patients treated with tegaserod
had significant improvements in abdominal pain and discomfort,
constipation, and overall well-being. Efficacy
was maintained throughout the treatment period.
Tegaserod also demonstrated significant improvements
in the three bowel-related assessments (stool frequency,
stool consistency, and straining) within the first week,
and these improvements were sustained throughout the
treatment period. The most common adverse events reported
thus far are headache and diarrhea.
Check Digit Verification of cas no
The CAS Registry Mumber 145158-71-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,1,5 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 145158-71:
(8*1)+(7*4)+(6*5)+(5*1)+(4*5)+(3*8)+(2*7)+(1*1)=130
130 % 10 = 0
So 145158-71-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H23N5O.C4H4O4/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15;5-3(6)1-2-4(7)8/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b20-11+;2-1+
145158-71-0Relevant articles and documents
New addition salt of N-amino-N'-pentylguanidine, the process for its preparation and use thereof for obtaining tegaserod
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Page/Page column 3, (2008/12/07)
The present invention refers to a new addition salt of N-amino-N'-pentylguanidine, particularly to the oxalate addition salt of N-amino-N'-pentylguanidine. The process for preparing said oxalate addition salt comprises the steps of: a) reacting the N-amino-N'-pentylguanidine, as a free base or in a salt form, with oxalic acid in a polar medium; and b) recovering the product in a solid form. This addition salt is useful for obtaining the tegaserod free base with a better purity and yield.