145348-25-0Relevant articles and documents
Synthesis and SAR of α-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors
Zhang, Yue-Mei,Fan, Xiaodong,Xiang, Bangping,Chakravarty, Devraj,Scannevin, Robert,Burke, Sharon,Karnachi, Prabha,Rhodes, Kenneth,Jackson, Paul
, p. 3096 - 3100 (2007/10/03)
A series of novel carboxylic acid-based α-sulfone MMP inhibitors have been synthesized and the in vitro enzyme SAR is discussed. A potential binding mode in the active site of the MMP-9 homology model was highlighted. These compounds are potent MMP-9 inhi