1458-03-3Relevant articles and documents
Synthesis method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid
-
Paragraph 0005; 0013-0015, (2021/07/21)
The invention belongs to medical intermediates, and particularly relates to a synthesis method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid. The 6-fluoro-3-hydroxypyrazine-2-carboxylic acid is prepared by taking a compound A, namely 3-aminopyrazine-2-carboxylic acid methyl ester as an initial raw material through five-step reaction, the synthetic method of the 6-fluoro-3-hydroxypyrazine-2-carboxylic acid is provided, a synthetic route is provided for the synthetic method of the 6-fluoro-3-hydroxypyrazine-2-carboxylic acid, the synthesis method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid provided by the invention is reasonable in design, simple to operate and easy to control, and meanwhile, the product obtained by the invention is relatively high in yield.
Large-scale process for preparing 2-amino-3-bromo-6-chloropyrazine
-
Paragraph 0032-0034, (2018/06/26)
The invention discloses a large-scale process for preparing 2-amino-3-bromo-6-chloropyrazine. The product is obtained from 3-aminopyrazine-2-carboxylate as a raw material through steps of chlorination, diazotization bromination, ester group hydrolysis, carboxyl rearrangement, t-butyloxycarbonyl removal and the like. The process is higher in yield, simple in purification, prone to large-scale production and capable of realizing effective and low-cost production.
Heterocyclic compounds
-
, (2008/06/13)
The invention concerns pharmaceutically useful compounds of the formula I, in which A1, A2, A3, A4, B1, m, Ar, W, X, Y, Z and R1 have any of the meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel compounds possess endothelin receptor antagonist activity and are useful, for example, in the treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.
