145915-60-2 Usage
Description
5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE, also known as CGP 53353, is a compound with a complex chemical structure that has been found to have significant biological activities. It is characterized by its ability to inhibit specific cellular processes, making it a potential candidate for various therapeutic applications.
Uses
Used in Pharmaceutical Industry:
5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE is used as an inhibitor for the tyrosine kinase activity of the EGF-R (Epidermal Growth Factor Receptor) for its potential role in cancer treatment. The compound has demonstrated the ability to inhibit the tyrosine kinase activity of the EGF-R in five different human transitional cell carcinoma lines, suggesting its potential use in targeting cancer cells and limiting their growth and proliferation.
Biological Activity
Selective inhibitor of PKC β II (IC 50 values are 0.41 and 3.8 μ M for PKC β II and PKC β I respectively). Also inhibits prionogenic Sup35 fibrillization (IC 50 ~ 3.4 μ M) and inhibits de novo A β 42 assembly in vitro .
Check Digit Verification of cas no
The CAS Registry Mumber 145915-60-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,9,1 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 145915-60:
(8*1)+(7*4)+(6*5)+(5*9)+(4*1)+(3*5)+(2*6)+(1*0)=142
142 % 10 = 2
So 145915-60-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H13F2N3O2/c21-11-1-5-13(6-2-11)23-17-9-15-16(20(27)25-19(15)26)10-18(17)24-14-7-3-12(22)4-8-14/h1-10,23-24H,(H,25,26,27)