146000-38-6Relevant articles and documents
An efficient and practical N-methylation of amino acid derivatives.
Prashad, Mahavir,Har, Denis,Hu, Bin,Kim, Hong-Yong,Repic, Oljan,Blacklock, Thomas J
, p. 125 - 128 (2003)
[reaction: see text] An efficient and practical N-methylation of amino acid derivatives with dimethyl sulfate in the presence of sodium hydride and a catalytic amount of water is described. Reaction of water with sodium hydride generated highly reactive dry sodium hydroxide, which led to much faster reaction rates than powdered sodium hydroxide itself.