146177-57-3 Usage
General Description
2-Amino-3,5-dimethylimidazo(4,5-f)quinoxaline is a chemical compound that belongs to the class of imidazoquinoxaline derivatives. It is a potent mutagen that has been found in cooked meat and tobacco smoke. It is formed during the cooking of meat at high temperatures, particularly through grilling or frying. Exposure to this chemical has been linked to an increased risk of various cancers, including colorectal, pancreatic, and breast cancer. The compound is currently being studied for its potential carcinogenic effects and its role in cancer development. Overall, 2-amino-3,5-dimethylimidazo(4,5-f)quinoxaline is a concerning chemical that is commonly found in the environment and may pose health risks to individuals exposed to it.
Check Digit Verification of cas no
The CAS Registry Mumber 146177-57-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,1,7 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 146177-57:
(8*1)+(7*4)+(6*6)+(5*1)+(4*7)+(3*7)+(2*5)+(1*7)=143
143 % 10 = 3
So 146177-57-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H11N5/c1-6-5-7-9(15-11(12)16(7)2)10-8(6)13-3-4-14-10/h3-5H,1-2H3,(H2,12,15)
146177-57-3Relevant articles and documents
Synthesis of Mutagenic Methyl- and Phenyl-substituted 2-Amino-3H-imidazoquinoxalines via 2,1,3-Benzoselenadiazoles
Grivas, Spiros,Tian, Wei,Ronne, Erik,Lindstroem, Stefan,Olsson, Kjell
, p. 521 - 528 (2007/10/02)
2-Amino-3-methyl-3H-imidazoquinoxaline, all its derivatives with 1-4 methyl groups in positions 4, 5, 7 and 8, and 2-amino-3,5-dimethyl-7,8-diphenyl-3H-imidazoquinoxaline have been synthesized from the corresponding 6-methylamino-5-nitroquinoxalines through reduction and cyclization with cyanogen bromide.The quinoxalines were obtained from the appropriate α-dicarbonyl compounds and 4-methylamino-3-nitro-1,2-benzenediamines.The latter were prepared from 4-halo-1,2-benzenediamines via 2,1,3-benzoselenadiazoles.The 7- and 8-phenyl derivatives of 2-amino-3,5-dimethyl-3H-imidazoquinoxaline have been synthesized in a slightly different way.
