14619-86-4Relevant articles and documents
Novel selenium-containing acenaphtho[1,2-b]pyrrole derivatives: Synthesis and bioactivity
Wang, Jisong,Yang, Fuli,Zheng, Liang,Ren, Gang,Qi, Jiude,Wang, Zhijun,Zhao, Liwei
, p. 715 - 718 (2016)
Seven novel selenium-containing acenaphtho[1,2-b]pyrrole derivatives were designed and synthesized and their cytotoxic effects were evaluated by the MTT tetrazolium dye assay. Two compounds presented good anticancer activities.
1-oxo-1H-phenalene-2,3-dicarbonitrile heteroaromatic scaffold: Revised structure and mechanistic studies
Lenk, Romaric,Tessier, Arnaud,Lefranc, Pierre,Silvestre, Virginie,Planchat, Aurlien,Blot, Virginie,Dubreuil, Didier,Lebreton, Jacques
, p. 9754 - 9761 (2014)
Synthesis of the originally proposed 8-oxo-8H-acenaphtho[1,2-b]pyrrol-9-carbonitrile led to a structural revision, and the product has now been identified as unknown compound 1-oxo-1H-phenalene-2,3-dicarbonitrile. The structural assignment was corroborate
A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction
Wang, Ziqian,Song, Ting,Guo, Zongwei,Uwituze, Laura B.,Guo, Yafei,Zhang, Hong,Wang, Hang,Zhang, Xiaodong,Pan, Hao,Ji, Tong,Yin, Fangkui,Zhou, Sheng,Dai, Jian,Zhang, Zhichao
, (2021)
Targeting cancer-related Hsp70-Bim protein-protein interactions (PPIs) offers a new strategy for the design of Hsp70 inhibitors. Herein, we discovered a novel Hsp70 inhibitor, S1g-6, based on the established BH3 mimetics. S1g-6 exhibited sub-μM binding af
One-pot, sequential four-component synthesis of novel heterocyclic [3.3.3] propellane derivatives at room temperature
Beyrati, Maryam,Hasaninejad, Alireza
, p. 14171 - 14176 (2018)
An efficient, one-pot, two-step, four-component reaction for the synthesis of propellane derivatives is described by the condensation reaction between acenaphthenequinone, malono derivatives, primary amines and β-ketoester or β-diketone derivatives in the presence of triethylamine in ethanol at room temperature. Using this procedure, all the products were obtained in good to excellent yields.
Light-induced activities of novel naphtho[1,8-ef]isoindole-7,8,10(9H)-trione and oxoisoaporphine derivatives towards mosquito larvae
Feng, Hao,Shao, Xusheng,Xu, Qi
, (2021)
Infected mosquitoes are significant vectors of dengue, yellow fever, chikungunya, zika and other pathogens. In the view of increasing resistance in mosquito larvae control, photoactivated insecticides is a promising approach by utilizing highly toxic singlet oxygen produced by photosensitizer through irradiation. However, the choice of photosensitizer for mosquito control is limited. Here, we report a novel series of naphtho[1,8-ef]isoindole-7,8,10(9H)-trione and oxoisoaporphines derivatives as excellent type II photosensitizers. Meanwhile, the light-dependent activities against permethrin-susceptible and permethrin-resistant strain of Aedes aegypti mosquito larvae of these compounds were evaluated. Among them, compound 7b was proved to be potential photodynamic insecticide due to its excellent phototoxicity, the LC50 value was 0.19 μg mL?1 under visible light irradiation. The irradiation-generated enhancement in the activity was more than 520-fold. This compound could be the potential candidate in the search for new photoactivated insecticide leads. Importantly, 7b has good fluorescence quantum yield (?F = 0.70), it can be used as a fluorescence indicator in mosquito larvae to observe uptake and morphology change.
Revisit of a series of ICT fluorophores: Skeletal characterization, structural modification, and spectroscopic behavior
Li, Honglin,Liu, Fengyu,Xiao, Yi,Pellechia, Perry J.,Smith, Mark D.,Qian, Xuhong,Wang, Guiren,Wang, Qian
, p. 5872 - 5877 (2014)
We have revisited the synthesis of a series of ICT fluorophores, which were reported to have a core structure of 8-oxo-8H-acenaphtho[1,2-b]pyrrol-9-carbonitrile. However, based on the 2D NMR and X-ray diffraction analysis, their core structure was correct
A new class of long-wavelength fluorophores: Strong red fluorescence, convenient synthesis and easy derivation
Xiao, Yi,Liu, Fengyu,Qian, Xuhong,Cui, Jingnan
, p. 239 - 241 (2005)
A new class of structurally simple fluorophores with strong long-wavelength emission have been developed through a very convenient procedure.
A Simplistic Approach for Preparation of Alkylidenemalononitrile Derivatives: Characterization, In silico Studies, Quantum Chemical Evaluation, Molecular Docking, and In vitro Biological Activity Evaluation
Ahmad, Rumana,Azad, Iqbal,Kamal, Azhar,Khan, Abdul Rahman,Khan, Tahmeena,Nasibullah, Malik
, (2020/11/24)
A new and efficient green grinding-based catalyst free Knoevenagel condensation of aldehydes/ketones and malononitrile for the rapid preparation of twelve malononitrile derivatives (C1-C12) is proposed. Characterization of the derivatives was done by sup
