146954-74-7

• 

• Basic information

  1. Product Name: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE
  2. Synonyms: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE;2'-Deoxy-5'-O-DMT-2'-fluoro-D-uridine;2'-Deoxy-5'-O-DMT-2'-fluorouridine;5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine;DMT-2'-F-dU;5'-O-(4,4'-DiMethoxytrityl)-2'-fluoro-2'-deoxyuridine;1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione;5'-O-DMT-2'-Fluoro-2'-deoxyuridine
  3. CAS NO:146954-74-7
  4. Molecular Formula: C₃₀H₂₉FN₂O₇
  5. Molecular Weight: 548.56
  6. EINECS: 2017-001-1
  7. Product Categories: N/A
  8. Mol File: 146954-74-7.mol
  9. Article Data: 27

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: White to Pale Yellow/Powder
  5. Density: 1.38 g/cm³
  6. Refractive Index: N/A
  7. Storage Temp.: 2-8°C
  8. Solubility: N/A
  9. PKA: 9.39±0.10(Predicted)
  10. CAS DataBase Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE(CAS DataBase Reference)
  11. NIST Chemistry Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE(146954-74-7)
  12. EPA Substance Registry System: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE(146954-74-7)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 146954-74-7(Hazardous Substances Data)

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• SDS
• Upstream product
• Downstream Products
• Article

146954-74-7 Suppliers

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• 5'-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2'-DEOXY-2'-FLUORO-URIDINE

  Cas No: 146954-74-7

• USD $ 3.0-3.0 / Kilogram

• 1 Kilogram

• 1-100 Metric Ton/Month

• Dayang Chem (Hangzhou) Co.,Ltd.
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• 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE

  Cas No: 146954-74-7

• USD $ 5.0-10.0 / Kilogram

• 1 Kilogram

• 100 Metric Ton/Month

• Hebei Sankai Chemical Technology Co., Ltd
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• Uridine,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-

  Cas No: 146954-74-7

• No Data

• No Data

• 10000 Metric Ton/Month

• Henan Wentao Chemical Product Co., Ltd.
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• 2'-Deoxy-5'-O-DMTr-2'-fluoro-uridine

  Cas No: 146954-74-7

• No Data

• 1 Milligram

• Kilogram/Month

• NewCan Biotech Limited
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• 2’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-2’-fluorouridine

  Cas No: 146954-74-7

• No Data

• 4 Kilogram

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• SHANGHAI T&W PHARMACEUTICAL CO., LTD.
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• Uridine,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-

  Cas No: 146954-74-7

• No Data

• No Data

• 5

• Hangzhou J&H Chemical Co., Ltd.
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• Uridine,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-

  Cas No: 146954-74-7

• No Data

• 10 Gram

• 500 Kilogram/Month

• Zibo Hangyu Biotechnology Development Co., Ltd
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• 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE

  Cas No: 146954-74-7

• USD $ 2.0-2.0 / Kilogram

• 1 Kilogram

• 10000000 Kilogram/Year

• TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD
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• 5'-DMT-2'-F-dU

  Cas No: 146954-74-7

• No Data

• 100 Gram

• 100 Metric Ton/Year

• Wuhu Nuowei Chemistry Technologies Co., Ltd.
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• 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione cas no. 146954-74-7 98%

  Cas No: 146954-74-7

• No Data

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• Win-Win chemical Co.Ltd
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146954-74-7 Usage

General Description

5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE is a chemical compound that is commonly used in the field of organic chemistry and biochemistry. It belongs to the family of uridine derivatives and is often utilized as a building block for the synthesis of various nucleoside analogs and nucleic acid-based drugs. The compound is known for its 2'-fluoro modification, which can improve the stability and binding affinity of nucleic acid structures. It is typically used in the production of modified RNA molecules for research and therapeutic purposes. Additionally, 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE may also have potential applications in antiviral drug development and nucleic acid-based diagnostics.

Check Digit Verification of cas no

The CAS Registry Mumber 146954-74-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,9,5 and 4 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 146954-74:
(8*1)+(7*4)+(6*6)+(5*9)+(4*5)+(3*4)+(2*7)+(1*4)=167
167 % 10 = 7
So 146954-74-7 is a valid CAS Registry Number.

146954-74-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione

1.2 Other means of identification

Product number	-
Other names	5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:146954-74-7 SDS

146954-74-7Upstream product

• 100-66-3 methoxybenzene 
• 98-07-7 Benzotrichlorid 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 622785-69-7 1-((2S,3S,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 56287-17-3 2'-deoxy-2'-fluorouridine 

146954-74-7Downstream Products

• 56287-17-3 2'-deoxy-2'-fluorouridine 

146954-74-7Relevant articles and documents

4'-HALOGEN CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO

-

Page/Page column 325, (2021/07/10)

Disclosed are halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections. Such viral infections can include tongaviridae, bunyaviridae, arenaviridae, coronaviridae, flaviviridae, picornaviridae, Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infections.

Copper(II)nitrate catalyzed regioselective protection of primary alcohols with 4,4′-dimethoxytrityl and 2,7-dimethyl-9-phenyl xanthen-9-yl groups in nucleosides and carbohydrates

Penjarla, Srishylam,Prasad, S. Rajendra,Reddy, Dhande Sudhakar,Banerjee, Shyamapada,Penta, Santhosh,Sanghvi, Yogesh S.

, p. 232 - 247 (2018/05/14)

Regioselective protection of primary hydroxyl group in nucleoside and carbohydrate analogs was accomplished using dimethoxytrityl alcohol (DMTr-OH) or dimethylpixyl alcohol (DMPx-OH) in presence of copper(II)nitrate as a Lewis acid catalyst. Excellent selectivity was observed for the protection of primary hydroxyl group over secondary while glycosidic bond remain unaffected. Utility of this methodology was further exemplified via DMTr- and DMPx-protection of alipahtic acyclic and cyclic diols.

ALKYNE CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO

-

Page/Page column 325, (2017/12/09)

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

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