146961-76-4

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• Basic information

  1. Product Name: Alatrofloxacin
  2. Synonyms: Alatrofloxacin (inn);D07562;UUZPPAMZDFLUHD-VUJLHGSVSA-N
  3. CAS NO:146961-76-4
  4. Molecular Formula: C26H25F3N6O5.CH4O3S
  5. Molecular Weight: 654.62
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 146961-76-4.mol
  9. Article Data: 0

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 863.2°C at 760 mmHg
  3. Flash Point: 475.8°C
  4. Appearance: /
  5. Density: 1.57g/cm³
  6. Vapor Pressure: 8.88E-32mmHg at 25°C
  7. Refractive Index: 1.673
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. PKA: 5.80±0.70(Predicted)
  11. CAS DataBase Reference: Alatrofloxacin(CAS DataBase Reference)
  12. NIST Chemistry Reference: Alatrofloxacin(146961-76-4)
  13. EPA Substance Registry System: Alatrofloxacin(146961-76-4)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 146961-76-4(Hazardous Substances Data)

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• Factory Price API 99% Alatrofloxacin 146961-76-4 GMP Manufacturer

  Cas No: 146961-76-4

• USD $ 0.1-0.1 / Gram

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• Xi'an Xszo Chem Co., Ltd.
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• L-Alaninamide,L-alanyl-N-[(1a,5a,6a)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-

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• 99% up by HPLC Alatrofloxacin 146961-76-4

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• Hebei Sankai Chemical Technology Co., Ltd
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• L-Alaninamide,L-alanyl-N-[(1a,5a,6a)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-

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• Antimex Chemical Limied
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• Alatrofloxacin CAS No.146961-76-4

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• Guangdong Juda Chemical Industrial Co.,Limited
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• Debye Scientific
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• L-Alaninamide,L-alanyl-N-[(1a,5a,6a)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-

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146961-76-4 Usage

Enzyme inhibitor

This fourth-generation fluoroquinolone-class antibiotic (FW = 558.51 g/mol; CAS 146961-76-4; quickly hydrolyzes to form trovafloxacin), also named 7-[(1R,5S)-6-{[(2S)-1-{[(2S)-2-aminopropanoyl]amino}-1-oxopropan- 2-yl]amino}-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6- fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid, is a systemic antibacterial that targets Type II DNA topoisomerases (gyrases) required for bacterial replication and transcription. This fluoroquinolone shows an extensive in vitro antibiotic spectrum, with high activity against Grampositive coccus, anaerobic and atypical pneumonia-producing bacteria. (For the prototypical member of this antibiotic class, See Ciprofloxacin) Intravenous alatrofloxacin, followed by oral trovafloxacin (TVX), is safe and well tolerated. Alatrofloxacin also lacks the phototoxicity, cardiovascular toxicity, and hemolytic anemia associated with earlier fluoroquinolones. Given its metabolism to trovafloxacin, it should be noted that the latter significantly increases the formation of nitrotyrosine in mice that are heterozygous for mitochondrial superoxide dismutase-2. Using the NO-selective probe DAF-2, TVX also increases the production of mitochondrial NO in immortalized human hepatocytes. Similarly, mitochondrial Ca2+ is increased by TVX, suggesting calcium ion-dependent activation of mitochondrial NOS activity. The relationship between these observations and trovafloxacin-induced leukopenia remains to be explored.

Check Digit Verification of cas no

The CAS Registry Mumber 146961-76-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,9,6 and 1 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 146961-76:
(8*1)+(7*4)+(6*6)+(5*9)+(4*6)+(3*1)+(2*7)+(1*6)=164
164 % 10 = 4
So 146961-76-4 is a valid CAS Registry Number.

InChI:InChI=1/C26H25F3N6O5/c1-10(30)24(37)31-11(2)25(38)32-20-14-7-34(8-15(14)20)23-18(29)6-13-21(36)16(26(39)40)9-35(22(13)33-23)19-4-3-12(27)5-17(19)28/h3-6,9-11,14-15,20H,7-8,30H2,1-2H3,(H,31,37)(H,32,38)(H,39,40)/t10-,11-,14-,15+,20?/m0/s1

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