Welcome to LookChem.com Sign In|Join Free

CAS

  • or

14756-22-0

Post Buying Request

14756-22-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

14756-22-0 Usage

General Description

2-(4-methoxyphenyl)-4H-benzo[h]chromen-4-one is a chemical compound with a complex structure belonging to the class of benzo[h]chromen-4-one derivatives. It contains a 4H-benzo[h]chromen-4-one core structure with a 4-methoxyphenyl substituent at the 2-position. 2-(4-methoxyphenyl)-4H-benzo[h]chromen-4-one has potential applications in the field of medicinal chemistry, particularly in the development of drugs with therapeutic properties. Its unique structure and functional groups make it an interesting target for pharmacological research. Additionally, it may have potential uses as a ligand in chemical synthesis or as a probe in chemical analysis.

Check Digit Verification of cas no

The CAS Registry Mumber 14756-22-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,7,5 and 6 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 14756-22:
(7*1)+(6*4)+(5*7)+(4*5)+(3*6)+(2*2)+(1*2)=110
110 % 10 = 0
So 14756-22-0 is a valid CAS Registry Number.

14756-22-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Methoxy-4'-.α.-naphthoflavone

1.2 Other means of identification

Product number -
Other names 4'-methoxy-7,8-benzoflavone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14756-22-0 SDS

14756-22-0Relevant articles and documents

-

Bhullar,Venkataraman

, p. 1165,1168 (1931)

-

Design and synthesis of selective CYP1B1 inhibitor via dearomatization of α-naphthoflavone

Kubo, Makoto,Yamamoto, Keiko,Itoh, Toshimasa

, p. 285 - 304 (2019/01/04)

Selective cytochrome P450 (CYP) 1B1 inhibition has potential as an anticancer strategy that is unrepresented in the current clinical arena. For development of a selective inhibitor, we focused on the complexity caused by sp3-hybridized carbons and synthesized a series of benzo[h]chromone derivatives linked to a non-aromatic B-ring using α-naphthoflavone (ANF) as the lead compound. Ring structure comparison suggested compound 37 as a suitable cyclohexyl-core with improved solubility. Structural evolution of 37 produced the azide-containing cis-49a, which had good properties in three important respects: (1) selectivity for CYP1B1 over CYP1A1 and CYP1A2 (120-times and 150-times, respectively), (2) greater inhibitory potency of >2 times that of ANF, and (3) improved solubility. The corresponding aromatic B-ring compound 59a showed low selectivity and poor solubility. To elucidate the binding mode, we performed X-ray crystal structure analysis, which revealed the interaction mode and explained the subtype selectivity of cis-49a.

Application of α- and β-naphthoflavones as monooxygenase inhibitors of Absidia coerulea KCh 93, Syncephalastrum racemosum KCh 105 and Chaetomium sp. KCh 6651 in transformation of 17α-methyltestosterone

Janeczko, Tomasz,Pop?oński, Jaros?aw,Koz?owska, Ewa,Dymarska, Monika,Huszcza, Ewa,Kostrzewa-Sus?ow, Edyta

, p. 178 - 184 (2018/03/26)

In this work, 17α-methyltestosterone was effectively hydroxylated by Absidia coerulea KCh 93, Syncephalastrum racemosum KCh 105 and Chaetomium sp. KCh 6651. A. coerulea KCh 93 afforded 6β-, 12β-, 7α-, 11α-, 15α-hydroxy derivatives with 44%, 29%, 6%, 5% and 9% yields, respectively. S. racemosum KCh 105 afforded 7α-, 15α- and 11α-hydroxy derivatives with yields of 45%, 19% and 17%, respectively. Chaetomium sp. KCh 6651 afforded 15α-, 11α-, 7α-, 6β-, 9α-, 14α-hydroxy and 6β,14α-dihydroxy derivatives with yields of 31%, 20%, 16%, 7%, 5%, 7% and 4%, respectively. 14α-Hydroxy and 6β,14α-dihydroxy derivatives were determined as new compounds. Effect of various sources of nitrogen and carbon in the media on biotransformations were tested, however did not affect the degree of substrate conversion or the composition of the products formed. The addition of α- or β-naphthoflavones inhibited 17α-methyltestosterone hydroxylation but did not change the percentage composition of the resulting products.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 14756-22-0