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1480-89-3

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1480-89-3 Usage

General Description

6-Fluoropurine is a chemical compound that is derived from the purine nucleoside adenosine. It is a synthetic analog of adenosine that contains a fluorine atom at the 6 position of the purine ring. This modification gives 6-fluoropurine unique properties and potential applications in medicinal chemistry and pharmaceutical research. It is known to exhibit activity as a purine nucleoside phosphorylase inhibitor, which makes it a potential candidate for the treatment of certain types of leukemia and autoimmune diseases. Additionally, 6-fluoropurine has also been studied for its potential anti-inflammatory and antiviral properties, making it a promising compound for further exploration in drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 1480-89-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,8 and 0 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1480-89:
(6*1)+(5*4)+(4*8)+(3*0)+(2*8)+(1*9)=83
83 % 10 = 3
So 1480-89-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H3FN4/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H,7,8,9,10)

1480-89-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Fluoropurine

1.2 Other means of identification

Product number -
Other names 1H-Purine,6-fluoro-(9CI)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1480-89-3 SDS

1480-89-3Relevant articles and documents

Kiburis,Lister

, p. 3942,3946 (1971)

The new convenient synthesis of 6-fluoropurine and its 7-/9-unsubstituted analogues

Deng, Mei,Wang, Ningyu,Xiang, Guangming,Yu, Luoting

, p. 2999 - 3006 (2013/02/23)

6-Fluoropurine and its 7-/9-unsubstituted analogues have good biological activity and serve as important pharmaceutical intermediates. This paper describes a new and convenient synthesis of 6-fluoropurine and its 7-/9-unsubstituted analogues, by first replacing the chlorine atoms with trimethylammonio groups through the reaction of 6-chloropurine and its 7-/9-unsubstituted analogues with trimethylamine, and then replacing the trimethylammonio groups with fluorine atoms using safe and cheap TBAF·3H2O as fluorinating agent at room temperature. Compared with reported methods, the new synthesis has milder conditions, shorter reaction times, simpler post-processing and higher (or similar) yields.

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