148022-00-8Relevant articles and documents
Synthesis of enterolactone and enterodiol precursors as potential inhibitors of human estrogen synthetase (aromatase)
Maekelae, Taru H.,Waehaelae, Kristiina T.,Hase, Tapio A.
, p. 437 - 441 (2000)
A series of variably substituted derivatives of lignan lactones and diols were prepared using tandem conjugate addition reaction as a key step. These theoretical precursors of the mammalian lignans enterolactone 1 and enterodiol 3 are moderate or weak inhibitors of human aromatase activity. (C) 2000 Elsevier Science Inc.
(-)-Arctigenin as a lead compound for anticancer agent
Chen, Gui-Rong,Li, Hong-Fu,Dou, De-Qiang,Xu, Yu-Bin,Jiang, Hong-Shuai,Li, Fu-Rui,Kang, Ting-Guo
supporting information, p. 2251 - 2255 (2014/01/06)
(-)-Arctigenin, an important active constituent of the traditional Chinese herb Fructus Arctii, was found to exhibit various bioactivities, so it can be used as a good lead compound for further structure modification in order to find a safer and more potent medicine. (-)-Arctigenin derivatives 1-5 of (-)-arctingen were obtained by modifying with ammonolysis at the lactone ring and sulphonylation at C (6′) and C (6″) and O-demethylation at CH3O-C (3′), CH3O-C (3″) and CH3O-C (4″), and their anticancer bioactivities were examined. 2013
Identification of lignans by liquid chromatography-electrospray ionization ion-trap mass spectrometry
Eklund, Patrik C.,Backman, M. Josefin,Kronberg, Leif A.,Smeds, Annika I.,Sjoeholm, Rainer E.
, p. 97 - 107 (2008/04/12)
The fragmentation pattern of 30 compounds belonging to different classes of the lignan family was studied by liquid chromatography-electrospray ionization ion-trap mass spectrometry. On the basis of the observed fragmentation patterns, identification of d
