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148383-07-7

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148383-07-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 148383-07-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,3,8 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 148383-07:
(8*1)+(7*4)+(6*8)+(5*3)+(4*8)+(3*3)+(2*0)+(1*7)=147
147 % 10 = 7
So 148383-07-7 is a valid CAS Registry Number.
InChI:InChI=1/C27H41N7O6/c28-18(15-35)23(36)33-20(13-16-7-2-1-3-8-16)24(37)34(22(26(39)40)11-6-12-31-27(29)30)25(38)21-14-17-9-4-5-10-19(17)32-21/h1-3,7-8,17-22,32,35H,4-6,9-15,28H2,(H,33,36)(H,39,40)(H4,29,30,31)/t17?,18-,19?,20+,21?,22-/m0/s1

148383-07-7Downstream Products

148383-07-7Relevant articles and documents

NMR and computational evidence that high-affinity bradykinin receptor antagonists adopt C-terminal β-turns

Kyle,Blake,Smithwick,Green,Martin,Sinsko,Summers

, p. 1450 - 1460 (2007/10/02)

Three tetrapeptides were prepared, each corresponding to the four C- terminal amino acid residues of highly potent, second-generation bradykinin receptor antagonists. The tetrapeptides are (IA) Ser-D-Phe-Oic-Arg, (IIA) Ser-D-Tic-Oic-Arg, and (IIIA) Ser-D-Hype(trans-propyl)-Oic-Arg. Solution conformations for each were determined by incorporating interproton distance restraints, determined by 2D NMR experiments performed in water at neutral pH, into a series of distance geometry/simulated annealing model building calculations. Similarly, systematic conformational analyses were performed for each using molecular mechanics calculations. Both the NMR-derived structures, as well as the calculated structures, are shown to adopt a β- turn as the primary conformation. Excellent agreement between the predicted structures and the NMR-derived structures is demonstrated. Aside from being the first examples of linear tetrapeptides reported to be ordered in aqueous solvent, the results presented support the hypothesis that high-affinity bradykinin receptor antagonists must adopt C-terminal β-turn conformations.

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