148930-18-1Relevant articles and documents
Synthesis and biological activity of 1,5-diaryl-3-alkylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones and 1,5-diaryl-4-carboxymethyl-tetrahydropyrrol-2,3-diones
Gein,Popov,Kolla,Popova
, p. 107 - 109 (2007/10/02)
By interaction of α-ketoglutaric acid with Schiff bases 1,5-diaryl-3-arylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones 1 were obtained. Hydrolysis of the latter, carried out with hydrochlorid acid gave 1,5-diaryl-3-hydroxy-4-carboxymethyl-2,5-dihydropyrrol-2-ones 2. On treatment of 2 with aryl-amines the starting compounds 1 were yielded. All compounds were tested for their antiphlogistic activity.
REACTION OF α-KETOGLUTARIC ACID WITH SCHIFF BASES
Gein, V. L.,Popov, A. V.,Andreichikov, Yu. S.
, p. 2291 - 2295 (2007/10/02)
1,5-Diaryl-3-arylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones were synthesized in the reaction of α-ketoglutaric acid with Schiff bases. Their hydrolysis in concentrated hydrochloric acid results in 1,5-diaryl-3-hydroxy-4-carboxymethyl-2,5-dihydropyrrol-2-ones. These latter are converted into the initial compounds when treated with arylamines. The heating of 1,5-diaryl-4-methoxycarbonyl-2,5-dihydropyrrol-2-ones and their 3-arylamino derivatives above the melting point leads to their decarboxylation, while the treatment with diphenyldiazomethane converts them into the corresponding benzhydryl ethers.