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14988-21-7

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14988-21-7 Usage

General Description

4-Acetylamino-3-methyl-benzenesulfonyl chloride is a chemical compound known for its use as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is a chlorinated derivative of 4-acetylamino-3-methylbenzenesulfonamide and is commonly used in the pharmaceutical industry in the production of various medicines. This chemical is known for its reactivity and is commonly used in organic synthesis as a reagent to introduce the sulfonyl chloride functional group, which is utilized in a wide range of chemical transformations. Despite its usefulness, it is important to handle this compound with extreme care due to its potentially hazardous properties and should only be used by trained professionals in a controlled environment.

Check Digit Verification of cas no

The CAS Registry Mumber 14988-21-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,9,8 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 14988-21:
(7*1)+(6*4)+(5*9)+(4*8)+(3*8)+(2*2)+(1*1)=137
137 % 10 = 7
So 14988-21-7 is a valid CAS Registry Number.

14988-21-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-acetamido-3-methylbenzenesulfonyl chloride

1.2 Other means of identification

Product number -
Other names N-acetyl-2-methyl-4-chlorosulphonylaniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14988-21-7 SDS

14988-21-7Relevant articles and documents

Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors

Pan, Chenghao,Nie, Wenwen,Wang, Jiao,Du, Jiamin,Pan, Zhichao,Gao, Jian,Lu, Yang,Che, Jinxin,Zhu, Hong,Dai, Haibin,Chen, Binhui,He, Qiaojun,Dong, Xiaowu

, (2021/09/06)

Aberrant activation of the fibroblast growth factor 19-fibroblast growth factor receptor 4 (FGF19-FGFR4) signaling pathway has been proved to promote hepatocellular carcinoma (HCC) proliferation. It is assumed that the first FGFR4 inhibitor BLU9931 did no

Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification

Sun, Xicheng,Qiu, Jian,Strong, Sarah A.,Green, Louis S.,Wasley, Jan W.F.,Blonder, Joan P.,Colagiovanni, Dorothy B.,Stout, Adam M.,Mutka, Sarah C.,Richards, Jane P.,Rosenthal, Gary J.

supporting information; experimental part, p. 2338 - 2342 (2012/04/18)

The enzyme S-nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs are implicated in the pathogenesis of many diseases including those in respiratory, gastrointestinal, and cardiovascular systems. The pyrrole based N6022 was recently identified as a potent, selective, reversible, and efficacious GSNOR inhibitor which is currently in clinical development for acute asthma. We describe here the synthesis and structure-activity relationships (SAR) of novel pyrrole based analogs of N6022 focusing on carboxamide modifications on the pendant N-phenyl moiety. We have identified potent and novel GSNOR inhibitors that demonstrate efficacy in an ovalbumin (OVA) induced asthma model in mice.

Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor

Romines, Karen R.,Freeman, George A.,Schaller, Lee T.,Cowan, Jill R.,Gonzales, Steve S.,Tidwell, Jeffrey H.,Andrews III, Clarence W.,Stammers, David K.,Hazen, Richard J.,Ferris, Robert G.,Short, Steven A.,Chan, Joseph H.,Boone, Lawrence R.

, p. 727 - 739 (2007/10/03)

Despite the progress of the past two decades, there is still considerable need for safe, efficacious drugs that target human immunodeficiency virus (HIV). This is particularly true for the growing number of patients infected with virus resistant to currently approved HIV drugs. Our high throughput screening effort identified a benzophenone template as a potential nonnucleoside reverse transcriptase inhibitor (NNRTI). This manuscript describes our extensive exploration of the benzophenone structure-activity relationships, which culminated in the identification of several compounds with very potent inhibition of both wild type and clinically relevant NNRTI-resistant mutant strains of HIV. These potent inhibitors include 70h (GW678248), which has in vitro antiviral assay IC50 values of 0.5 nM against wild-type HIV, 1 nM against the K103N mutant associated with clinical resistance to efavirenz, and 0.7 nM against the Y181C mutant associated with clinical resistance to nevirapine. Compound 70h has also demonstrated relatively low clearance in intravenous pharmacokinetic studies in three species, and it is the active component of a drug candidate which has progressed to phase 2 clinical studies.

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