15000-41-6Relevant articles and documents
4-HYDROXY-2-QUINOLONES. 1. EFFICIENT METHOD FOR OBTAINING 3-ALKYL-4-HYDROXY-2-QUINOLONES
Bezuglyi, P.A.,Ukrainets, I.V.,Treskach, V.I.,Turov, A.V.
, p. 1237 - 1238 (1991)
3-Alkyl-4-hydroxy-2-quinolones were obtained in high yields via the Dieckmann intramolecular condensation of substituted malonic acid ethyl ester 2-carbalkoxyanilides.
One-step Synthesis of 3-Unsubstituted 4-Hydroxy-2(1H)-Quinoline
Menglin, Ma,Qingrong, Sun,Weiqing, Yang,Xingyi, Wang,Yinan, Xu
, p. 435 - 441 (2021/11/22)
3-Unsubstituted 4-hydroxy-2(1H)-quinolone (DHQ) derivatives were synthesized from aniline derivatives and diethyl malonate at low temperature using AlCl3 as catalyst and Eaton reagent as acidic environment. A reaction mechanism was proposed and elucidated. Different synthetic intermediates are specially prepared or purified and used to understand the reaction and validation mechanism.
Stereochemistry of the reduction of α-chloroketones with sodium borohydride—application to 3-chloroquinoline-2,4-diones: Dedicated to the memory of Professor Dr.?Vojeslav ?těrba who died in September 2015 being nearly 93 years old
Klásek, Antonín,Ly?ka, Antonín,K?emen, Filip,Rouchal, Michal
, p. 4490 - 4497 (2016/07/07)
3-Chloroquinoline-2,4-diones were reduced with sodium borohydride to give syn- and anti-chlorohydrins, the stereochemistry of which was established by NMR spectroscopy. Both stereoisomeric chlorohydrins were reacted with potassium carbonate in methanol. a
