15084-55-6 Usage
General Description
7-BROMO-3,4-DIHYDRO-2H-1-BENZOTHIEPIN-5-ONE, also known as zotepine, is a chemical compound with potential antipsychotic properties. It is a dibenzothiepin derivative with a bromine substituent at the 7 position. Zotepine functions by blocking the action of dopamine and serotonin receptors in the brain, which can help alleviate symptoms of psychosis and schizophrenia. It is used in the treatment of various psychiatric disorders, and its mechanism of action is similar to that of other atypical antipsychotic drugs. Zotepine has also shown potential for improving cognitive function and reducing negative symptoms associated with schizophrenia.
Check Digit Verification of cas no
The CAS Registry Mumber 15084-55-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,0,8 and 4 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 15084-55:
(7*1)+(6*5)+(5*0)+(4*8)+(3*4)+(2*5)+(1*5)=96
96 % 10 = 6
So 15084-55-6 is a valid CAS Registry Number.
15084-55-6Relevant articles and documents
Synthesis of 1-benzothiepine and 1-benzazepine derivatives as orally active CCR5 antagonists
Aramaki, Yoshio,Seto, Masaki,Okawa, Tomohiro,Oda, Tsuneo,Kanzaki, Naoyuki,Shiraishi, Mitsuru
, p. 254 - 258 (2007/10/03)
Quaternary ammonium benzocycloheptene compound 1 has previously been reported as a clinical candidate for an injectable CCR5 antagonist. In order to develop an orally active CCR5 antagonist, derivatives of tertiary amine benzocycloheptene 2, the chemical precursor to 1, were investigated. The benzocycloheptene ring was converted to benzothiepine and benzazepine rings and it was found that these changes could enhance the potency of tertiary amine derivatives. In particular, the 1-benzothiepine-1,1-dioxide 11b and the N-methyl-1-benzazepine 18 showed increased activity and good preliminary pharmacokinetic properties. The synthesis of 1-benzothiepine and 1-benzazepine derivatives and their activity are described.
