15121-92-3Relevant articles and documents
2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES
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, (2008/06/13)
Use in the prevention and/or in the treatment of neurodegenerative diseases of 2-amino-4-phenyl-4-oxo-butyric acid derivatives which act as kynureninase enzyme inhibitors and/or kynurenine-3-hydroxylase enzyme inhibitors. Several of these derivatives are new and, as such, constitute a further object of this invention, together with the process for their preparation and the pharmaceutical compositions containing them.
THE SYNTHESIS OF AMINO ACIDS BY REACTION OF AN ELECTROPHILIC GLYCINE CATION EQUIVALENT WITH NEUTRAL CARBON NUCLEOPHILES
O'Donell, Martin J.,Benett, William D.
, p. 5389 - 5402 (2007/10/02)
Seven neutral carbon nucleophiles (active aromatics, allylsilanes and a silyl enol ether) were reacted with the glycine cation equivalent 12 in the presence of TiCl4 to yield α-substituted amino acid derivatives in moderate yield (1-61.5 mmolar scale).Deprotection of the Schiff base ester products led to the corresponding amino acids.
