1514-15-4Relevant articles and documents
Palladium catalyzed domino C-H activation strategy: An access to 9- fluorenones
Patel, Anuj,Shaikh, Mahommedumar,Chikhalia, Kishor
, p. 236 - 245 (2019)
Palladium catalyzed domino C-H functionalization reaction of arylaldehyde with dihaloarene has been developed to access 9-flourenone molecules. Bidentate ligand assisted strategy, single step reaction, high yield and excellent functional group tolerance make this method concise and effective for the synthesis of 9-flourenone. In addition, proposed method has been successfully employed to synthesise Tilorone in gram scale.
Palladium-catalyzed cyclocarbonylation of cyclic diaryliodoniums: Synthesis of fluorenones
Liu, Li,Qiang, Jian,Bai, Shuhua,Li, Yang,Miao, Chunbao,Li, Jian
, (2017)
An efficient approach to the synthesis of fluorenones via the palladium-catalyzed cyclocarbonylation of cyclic diaryliodoniums was developed. Our route enables facile access to fluorenones with various substituents in modest to high yields.
Palladium-catalyzed intramolecular aromatic C-H acylation of 2-arylbenzoyl fluorides
Hayakawa, Kazuki,Ikai, Kana,Ogiwara, Yohei,Sakai, Norio,Sakurai, Yuka
, p. 1882 - 1893 (2021/08/13)
The catalytic intramolecular cyclization of acyl fluorides using a Pd(OAc)2/PCy3 system is described. A wide range of 2-arylbenzoyl fluoride derivatives can be used as fluorenone precursors and the reaction proceeds via an intramolecular coupling between aromatic C-H bonds with acyl C-F bonds. The reaction can be applied to the synthesis of indenofluorenedione derivatives and to the construction of other molecules with fivemembered rings.
Method for synthesizing fluorenone ketone compound through molecular oxygen oxidation in water phase
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Paragraph 0067-0068, (2019/08/20)
Aiming at the technical problems that in the prior art a method for synthesizing a fluorenone ketone compound has organic solvent pollution and byproducts can be generated, the invention provides a method for synthesizing a fluorenone ketone compound through molecular oxygen oxidation in a water phase. The method comprises the following steps: by taking a fluorenone compound as a substrate, dispersing into an alkali solution, and at 40-120 DEG C, in the presence of oxygen, and with a water-soluble transition metal compound as a catalyst, stirring to carry out reactions, thereby obtaining the fluorenone ketone compound. By adopting the method, molecular oxygen is adopted as an oxidant, and water is adopted as a solvent, so that an organic solvent is avoided, and the problem that multiple byproducts are generated because of peroxidation can be avoided.
