15145-41-2 Usage
General Description
1-(2-chloroethyl)-3-(2-methoxyphenyl)-1-nitrosourea, also known as nimustine, is a chemotherapy drug used in the treatment of various types of cancer, including brain tumors, lung cancer, and lymphoma. It belongs to the class of alkylating agents and works by inhibiting the growth of cancer cells. Nimustine is administered intravenously and is known to cross the blood-brain barrier, making it an effective treatment for brain tumors. It has also shown to have a relatively low level of toxicity compared to other chemotherapy drugs. However, it may cause side effects such as nausea, vomiting, and myelosuppression. Overall, nimustine has been a valuable addition to the arsenal of chemotherapy drugs for the treatment of various cancers.
Check Digit Verification of cas no
The CAS Registry Mumber 15145-41-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,1,4 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 15145-41:
(7*1)+(6*5)+(5*1)+(4*4)+(3*5)+(2*4)+(1*1)=82
82 % 10 = 2
So 15145-41-2 is a valid CAS Registry Number.
15145-41-2Relevant articles and documents
The relationship between solvatochromic properties and in silico ADME parameters of new chloroethylnitrosourea derivatives with potential anticancer activity and their β-Cyclodextrin complexes
Fisli, Hassina,Hennig, Andreas,Chelaghmia, Mohamed Lyamine,Abdaoui, Mohamed
supporting information, (2021/02/27)
In view of the anticancer effect of nitrosoureas a set of four new N-(2-chloroethyl)-N-nitrosourea (CENU) derivatives was synthesized. An in silico absorption, distribution, metabolism, excretion and toxicity (ADME/Tox) prediction study revealed that the
