1518-61-2Relevant articles and documents
PROCESS FOR PRODUCTION OF BETAINE
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Page/Page column 22, (2009/09/26)
According to the present invention, by using 4-halogeno-3-hydroxybutanamide as a substrate in quaternary amination reaction with trialkylamine which is an important step in betaine (such as carnitine) preparation processes, it becomes possible to reduce the production of crotonic acid derivatives (the major by-product) greatly compared to conventional processes. Consequently, it becomes possible to prepare a betaine, such as carnitine, at a high yield. The present invention also relates to a process for preparing a betaine represented by formula (1) below, comprising a step of quaternary aminating an amide represented by formula (2) below: wherein A1, A2 and A3 individually represent a C1-C20 hydrocarbon group which may have a substituent(s); and X1 is a halogen atom.
Method for preparing optically active 3,4-dihydroxy butyric acid derivatives
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, (2008/06/13)
The present invention presents a method for preparation of S-3,4-dihydroxy butyronitrile expressed by the structural formula (II) STR1 characterized by causing R-3-chloro-1,2-propanediol expressed by the structural formula (I) STR2 to react with a cyanating agent. According to this invention, optically active 3,4-dihydroxy butyronitrile and 3,4-dihydroxy butyric acid derivatives may be manufactured economically and efficiently.