152123-52-9Relevant articles and documents
Selenium- and palladium-catalyzed oxidative cleavage of ene-lactams with hydrogen peroxide. Convenient methods for synthesis of macrocyclic ketoimides and N-fused azabicyclic compounds
Naota, Takeshi,Sasao, Shigehiro,Tanaka, Kojiro,Yamamoto, Hideo,Murahashi, Shun-Ichi
, p. 4843 - 4846 (1993)
Oxidative cleavage of ene-lactams can be performed efficiently by either SeO2 or Pd(OAc)2-catalyzed oxidation with H2O2 to give the corresponding ketoimides. The reaction provides convenient methods for the preparation of macrocyclic ketoimides and the construction of N-fused azabicyclic ring systems such as indolizidine and cephalotaxine skeletons.