15332-10-2Relevant articles and documents
Ruthenium(ii)-catalysed 1,2-selective hydroboration of aldazines
Gunanathan, Chidambaram,Pradhan, Subham,Thiyagarajan, Subramanian
supporting information, p. 7147 - 7151 (2021/08/30)
Herein, an efficient and simple catalytic method for the selective and partial reduction of aldazines using ruthenium catalyst [Ru(p-cymene)Cl2]2 (1) has been accomplished. Under mild conditions, aldazines undergo the addition of pinacolborane in the presence of a ruthenium catalyst, which delivered N-boryl-N-benzyl hydrazone products. Notably, the reaction is highly selective, and results in exclusive mono-hydroboration and desymmetrization of symmetrical aldazines. Mechanistic studies indicate the involvement of in situ formed intermediate [{(η6-p-cymene)RuCl}2(μ-H-μ-Cl)] (1a) in this selective hydroboration.
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5
O'Brien, Julie A.,Lemaire, Wei,Chen, Tsing-Bau,Chang, Raymond S. L.,Jacobson, Marlene A.,Ha, Sookhee N.,Lindsley, Craig W.,Schaffhauser, Herve J.,Sur, Cyrille,Pettibone, Douglas J.,Conn, P. Jeffrey,Williams Jr., David L.
, p. 731 - 740 (2007/10/03)
We have identified a family of highly selective allosteric modulators of the group I metabotropic glutamate receptor subtype 5 (mGluR5). This family of closely related analogs exerts a spectrum of effects, ranging from positive to negative allosteric modu
