15384-21-1Relevant articles and documents
Enzymatic synthesis of new hepoxilins and trioxilins from polyunsaturated fatty acids
Lee, In-Gyu,An, Jung-Ung,Ko, Yoon-Joo,Park, Jin-Byung,Oh, Deok-Kun
, p. 3172 - 3181 (2019/06/18)
Hepoxilins (HXs) and trioxilins (TrXs) are lipid mediators that regulate diverse physiological processes at trace amounts in humans. They have been synthesized by chemical methods, which have disadvantages such as low yield, byproduct formation, and use of toxic chemical reagents. Here, we reported the identification of ten types of HXs and TrXs synthesized by recombinant Escherichia coli expressing bacterial arachidonate 15-lipoxygenase and/or epoxide hydrolase using five polyunsaturated fatty acids (PUFAs). Of these, eight types were new. The discovery was due to the microbial enzymes with high activities for the same catalytic activities as those of human enzymes. We succeeded in the efficient, cost-effective, and environmentally friendly biotransformation of PUFAs into nine types of HXs and TrXs by cells, yielding >10 g L-1 of 14,15-HXB3 and 13,14,15-TrXB3, with conversion yields of >70%. Our study contributes to the environmentally friendly synthesis of medicinally important lipid mediators.
PHARMACEUTICALLY ACCEPTABLE SALTS OF POLYUNSATURATED HYDROXY FATTY ACIDS
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Paragraph 00144-00147, (2015/06/03)
The present disclosure provides pharmaceutically acceptable stable salt forms of 15-lipoxygenase products, such as 15-HETrE lysine salt, compositions comprising same and methods of making and using same.
Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues
Haviv,Ratajczyk,DeNet,Martin,Dyer,Carter
, p. 254 - 263 (2007/10/02)
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