154186-65-9

• 

• Basic information

  1. Product Name: 4-[(4-benzyl-5-oxo-3,4-diazabicyclo[4.1.0]hept-2-en-2-yl)oxy]-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromene-6-carbonitrile
  2. Synonyms: 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-2,2-dimethyl-3-hydroxy-4-((5-oxo-4-(phenylmethyl)-3,4-diazabicyclo(4.1.0)hept-2-en-2-yl)oxy)-
  3. CAS NO:154186-65-9
  4. Molecular Formula: C₂₄H₂₃N₃O₄
  5. Molecular Weight: 417.4571
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 154186-65-9.mol
  9. Article Data: 2

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 584.9°C at 760 mmHg
  3. Flash Point: 307.5°C
  4. Appearance: N/A
  5. Density: 1.39g/cm³
  6. Vapor Pressure: 1.6E-14mmHg at 25°C
  7. Refractive Index: 1.686
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: 4-[(4-benzyl-5-oxo-3,4-diazabicyclo[4.1.0]hept-2-en-2-yl)oxy]-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromene-6-carbonitrile(CAS DataBase Reference)
  11. NIST Chemistry Reference: 4-[(4-benzyl-5-oxo-3,4-diazabicyclo[4.1.0]hept-2-en-2-yl)oxy]-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromene-6-carbonitrile(154186-65-9)
  12. EPA Substance Registry System: 4-[(4-benzyl-5-oxo-3,4-diazabicyclo[4.1.0]hept-2-en-2-yl)oxy]-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromene-6-carbonitrile(154186-65-9)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 154186-65-9(Hazardous Substances Data)

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154186-65-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 154186-65-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,1,8 and 6 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 154186-65:
(8*1)+(7*5)+(6*4)+(5*1)+(4*8)+(3*6)+(2*6)+(1*5)=139
139 % 10 = 9
So 154186-65-9 is a valid CAS Registry Number.

154186-65-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name	4-[(4-benzyl-5-oxo-3,4-diazabicyclo[4.1.0]hept-2-en-2-yl)oxy]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carbonitrile

1.2 Other means of identification

Product number	-
Other names	2H-1-Benzopyran-6-carbonitrile,3,4-dihydro-2,2-dimethyl-3-hydroxy-4-((5-oxo-4-(phenylmethyl)-3,4-diazabicyclo(4.1.0)hept-2-en-2-yl)oxy)

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:154186-65-9 SDS

154186-65-9Upstream product

• 64-17-5 ethanol 
• 65018-90-8 6-cyano-2,2-dimethylchromene-3,4-epoxide 
• 273213-48-2 (+/-)-3-benzyl-3,4-diazabicyclo[4.1.0]heptane-2,5-dione 
• 555-96-4 Benzylhydrazine 
• 5617-74-3 3-oxabicyclo[3.1.0]hexane-2,4-dione 

154186-65-9Downstream Products

154186-65-9Relevant articles and documents

Novel potassium channel opener prodrugs with a slow onset and prolonged duration of action

Horino, Haruhiko,Mimura, Tetsuya,Kobayashi, Syozo,Ohta, Masahiro,Kubo, Hideo,Ito, Kuniko,Tsumura, Mitsuyoshi,Kitagawa, Masayuki

, p. 490 - 495 (2007/10/03)

(-)-(3S,4R,1'R,6'S)-4-(4-Benzyl-5-oxo-3,4-diazabicyclo[4.1.0.]hept-2-en- 2-yloxy)-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile and its derivatives with a modified benzyl group were synthesized with the objective of discovering novel ATP-sensitive potassium channel openers (PCOs) with a slow onset of action and a reduced tendency to induce tachycardia. Among the compounds synthesized, 4-(2-chlorobenzyl) derivative 5bB had potent hypotensive activity in spontaneously hypertensive rats (SHRs). In addition, compound 5bB showed the desired pharmacological profile with a slow onset and long duration of action and induction of only mild tachycardia. Compound 5bB was found to be quantitatively metabolized in rats to give active des-2- chlorobenzyl derivative 6B. These results suggest that the incorporation of an N-benzyl group is a useful method for the preparation of prodrugs, the function of which is to delay the onset and prolong the duration of action of the active substance.

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