154784-36-8

• 

• Basic information

  1. Product Name: 1,1[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol(Mixture of diastereomers)
  2. Synonyms: 1,1[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol(Mixture of diastereomers);Metoprolol Impurity O;Metoprolol Impurity VII;Metoprolol Impurity VIII;Metoprolol Related compound D;(+/-)N,N-bis-[2-hydroxy-3-[4-(2-Methoxyethyl)phenoxy]propyl](1-Methylethyl)aMine hydrochloride;1,1'-[(1-Methylethyl)iMino]bis[3-[4-(2-Methoxyethyl)phenoxy]-2-propanol (Mixture of DiastereoMers) (Metoprolol IMpurity);Metoprolol Tartrate EP IMpurity-O (USP RC D-HCl Salt)
  3. CAS NO:154784-36-8
  4. Molecular Formula: C₂₇H₄₁NO₆
  5. Molecular Weight: 475.62
  6. EINECS: N/A
  7. Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
  8. Mol File: 154784-36-8.mol
  9. Article Data: 2

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 608.3±55.0 °C(Predicted)
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: 1.109±0.06 g/cm3(Predicted)
  6. Refractive Index: 1.541
  7. Storage Temp.: Refrigerator
  8. Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
  9. PKA: 13.52±0.20(Predicted)
  10. CAS DataBase Reference: 1,1[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol(Mixture of diastereomers)(CAS DataBase Reference)
  11. NIST Chemistry Reference: 1,1[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol(Mixture of diastereomers)(154784-36-8)
  12. EPA Substance Registry System: 1,1[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol(Mixture of diastereomers)(154784-36-8)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 154784-36-8(Hazardous Substances Data)

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• SDS
• Upstream product
• Downstream Products
• Article

154784-36-8 Suppliers

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• Metoprolol Related CoMpound D;(+/-)N,N-bis-[2-hydroxy-3-[4-(2-Methoxyethyl)phenoxy]propyl](1-Methylethyl)aMine hydrochloride;

  Cas No: 154784-36-8

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• Henan Allgreen Chemical Co.,Ltd
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• 1,1’-[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol(Mixture of Diastereomers)(Metoprolol Impurity)

  Cas No: 154784-36-8

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• BOC Sciences
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• 1,1[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol_x000b_(Mixture of diastereomers) CAS No.154784-36-8

  Cas No: 154784-36-8

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• Guangdong Juda Chemical Industrial Co.,Limited
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• Metoprolol RC D ( EP IMP O)

  Cas No: 154784-36-8

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• Simson Pharma Limited
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• 1,1'-[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol

  Cas No: 154784-36-8

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• Finetech Industry Limited
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• Metoprolol USP Related Compound D

  Cas No: 154784-36-8

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• Topbatt Chemical Co., Ltd.
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• Metoprolol USP Related Compound D

  Cas No: 154784-36-8

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• Shenzhen Sumshine Biotech Co., Ltd.
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154784-36-8 Usage

Chemical Properties

Yellow Oil

Uses

Different sources of media describe the Uses of 154784-36-8 differently. You can refer to the following data:
1. 1,1’-[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol (Metoprolol EP Impurity O) is an impurity of Metoprolol.
2. Impurity of Metoprolol

Check Digit Verification of cas no

The CAS Registry Mumber 154784-36-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,7,8 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 154784-36:
(8*1)+(7*5)+(6*4)+(5*7)+(4*8)+(3*4)+(2*3)+(1*6)=158
158 % 10 = 8
So 154784-36-8 is a valid CAS Registry Number.

InChI:InChI=1/C27H41NO6/c1-21(2)28(17-24(29)19-33-26-9-5-22(6-10-26)13-15-31-3)18-25(30)20-34-27-11-7-23(8-12-27)14-16-32-4/h5-12,21,24-25,29-30H,13-20H2,1-4H3

154784-36-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name	1-[[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]-propan-2-ylamino]-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol

1.2 Other means of identification

Product number	-
Other names	Metoprolol Related compound D

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:154784-36-8 SDS

154784-36-8Upstream product

• 75-31-0 isopropylamine 
• 56718-70-8 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane 

154784-36-8Downstream Products

154784-36-8Relevant articles and documents

CONTINUOUS FLOW SYNTHESIS OF AMINO ALCOHOLS USING MICROREACTORS

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Page/Page column 10-11, (2011/06/10)

The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.

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