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154932-68-0

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154932-68-0 Usage

General Description

5-methoxy-2-(pyridin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one is a chemical compound that belongs to the class of indenone derivatives. It is a synthetic compound with potential pharmacological properties and is being studied for its potential therapeutic applications. 5-methoxy-2-(pyridin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one has a methoxy group and a pyridin-4-ylmethyl group attached to the indenone core, which gives it unique chemical properties and potential biological activities. Further research is needed to fully understand the chemical and biological properties of 5-methoxy-2-(pyridin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one and to explore its potential applications in medicine and other industries.

Check Digit Verification of cas no

The CAS Registry Mumber 154932-68-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,9,3 and 2 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 154932-68:
(8*1)+(7*5)+(6*4)+(5*9)+(4*3)+(3*2)+(2*6)+(1*8)=150
150 % 10 = 0
So 154932-68-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H15NO2/c1-19-14-2-3-15-12(10-14)9-13(16(15)18)8-11-4-6-17-7-5-11/h2-7,10,13H,8-9H2,1H3

154932-68-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-methoxy-2-(pyridin-4-ylmethyl)-2,3-dihydroinden-1-one

1.2 Other means of identification

Product number -
Other names I02-2829

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:154932-68-0 SDS

154932-68-0Downstream Products

154932-68-0Relevant articles and documents

Aromatase inhibitors. Syntheses and structure-activity studies of novel pyridyl-substituted indanones, indans, and tetralins

Hartmann,Bayer,Grun

, p. 1275 - 1281 (1994)

The (E)-2-(4-pyridylmethylene)-1-indanones (E)-1-(E)-5 [(E)-1, H; (E)-2, 4-OCH3; (E)-3, 5-OCH3; (E)-4, 4-OH; (E)-5, 5-OH] were obtained by aldol condensation of the corresponding 1-indanones with 4-pyridinecarboxaldehyde, and in case of the OH compound (E)-4 subsequent ether cleavage of (E)-2. The synthesis of the (Z)-isomers (Z)-1-(Z)-3 [(Z)-1, H; (Z)-2, 4-OCH3; (Z)-3, 5- OCH3] was accomplished by UV irradiation of the corresponding (E)-isomers. Catalytic hydrogenation of (E)-1-(E)-3 gave the 2-(4-pyridylmethyl)-1- indanones 6-8 (6, H; 7, 4-OCH3; 8, 5-OCH3). The 2-(4-pyridylmethyl)- substituted indans 11-13 (11, H; 12, 4-OCH3; 13, 5-OCH3) and the tetralins 16-19 (16, H; 17, 5-OCH3; 18, 6-OCH3; 19, 7-OCH3) were obtained by reduction of the corresponding ketones using N2H4/KOH. The 2-(4- pyridylmethyl)-substituted indanones 9 (4-OH) and 10 (5-OH), indans 14 (4- OH) and 15 (5-OH), and tetralins 20-22 (20, 5-OH; 21, 6-OH; 22, 7-OH) were synthesized by ether cleavage of the corresponding OCH3 compounds. All compounds showed inhibition of human placental aromatase exhibiting relative potencies from 0.9 [(E)-4] to 163 [18; aminoglutethimide (AG) potency χ 1]. Compounds 13 and 18 showed competitive type of inhibition and a type II difference spectrum, indicating the interaction of the pyridyl-N with the central Fe(III) ion of the cytochrome P450 heme component. Only the OH- substituted indans and tetralins inhibited bovine adrenal desmolase with maximum activity shown by 20 and 22 (12% inhibition, 25 μM; AG, 53% inhibition, 25 μM). In vivo, however, all tested aromatase inhibitors (6, 8, 10, 14, 15, 18 and 20) were less active than AG concerning the inhibition of the uterotrophic activity of androstenedione (6, 8, 10, 15), the reduction of the plasma estradiol concentration (14, 20), and the mammary carcinoma (MC) inhibiting properties (18, 20; androstenedione-stimulated juvenile rats, pregnant mares' serum gonadotropin-primed rats as well as dimethylbenzanthracene-induced MC of the Sprague-Dawley rat, postmenopausal experiment). Since no affinity to the estrogen receptor was demonstrated (20), estrogenic effects as a cause for the poor tumor inhibiting activity have to be excluded.

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